Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels

Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded... roca@bioforge.uva.es Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain Servicio de Traumatología y Cirugía Ortopédica, Hospital Universitario de Salamanca, Salamanca, Spain BIOFORGE Lab, Universidad de Valladolid, CIBER-BBN, Paseo de Belén, 19, 47011 Valladolid, Spain Technical Proteins Nanobiotechnology (TPNBT), Valladolid, Spain Unidad de Terapia Celular. Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain 1 Introduction Departamento de Biología Celular y Patología, Universidad de Salamanca, Salamanca, Spain Osteochondral injuries are a frequent source of pain and Servicio de Radiodiagnóstico, Hospital Virgen de la Concha de Zamora, Zamora, Spain disability and can even result in secondary osteoarthritis [1]. 115 Page 2 of 11 J Mater Sci: Mater Med (2017) 28:115 This disease has an enormous economic impact in devel- well-known RGD cell-adhesion sequence, which promotes oped countries, mostly due to ageing [2]. One of the main specific cell attachment via integrins [13], leads to an issues in this regard is that articular cartilage possesses injectable scaffold that provides a cell-friendly limited regeneration ability due to its avascularity and the environment. cellular and interstitial structure that sustains the bio- With regard to the tracking of cartilage regeneration, mechanical requirements of joints [3]. As such, it is easy to non-invasive imaging techniques http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Materials Science: Materials in Medicine Springer Journals

Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Materials Science; Biomaterials; Biomedical Engineering; Regenerative Medicine/Tissue Engineering; Polymer Sciences; Ceramics, Glass, Composites, Natural Materials; Surfaces and Interfaces, Thin Films
ISSN
0957-4530
eISSN
1573-4838
D.O.I.
10.1007/s10856-017-5928-1
Publisher site
See Article on Publisher Site

Abstract

roca@bioforge.uva.es Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain Servicio de Traumatología y Cirugía Ortopédica, Hospital Universitario de Salamanca, Salamanca, Spain BIOFORGE Lab, Universidad de Valladolid, CIBER-BBN, Paseo de Belén, 19, 47011 Valladolid, Spain Technical Proteins Nanobiotechnology (TPNBT), Valladolid, Spain Unidad de Terapia Celular. Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain 1 Introduction Departamento de Biología Celular y Patología, Universidad de Salamanca, Salamanca, Spain Osteochondral injuries are a frequent source of pain and Servicio de Radiodiagnóstico, Hospital Virgen de la Concha de Zamora, Zamora, Spain disability and can even result in secondary osteoarthritis [1]. 115 Page 2 of 11 J Mater Sci: Mater Med (2017) 28:115 This disease has an enormous economic impact in devel- well-known RGD cell-adhesion sequence, which promotes oped countries, mostly due to ageing [2]. One of the main specific cell attachment via integrins [13], leads to an issues in this regard is that articular cartilage possesses injectable scaffold that provides a cell-friendly limited regeneration ability due to its avascularity and the environment. cellular and interstitial structure that sustains the bio- With regard to the tracking of cartilage regeneration, mechanical requirements of joints [3]. As such, it is easy to non-invasive imaging techniques

Journal

Journal of Materials Science: Materials in MedicineSpringer Journals

Published: Jun 24, 2017

References

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