Refined genetic and comparative physical mapping of the canine copper toxicosis locus

Refined genetic and comparative physical mapping of the canine copper toxicosis locus Recently, the copper toxicosis (CT) locus in Bedlington terriers was assigned to canine chromosome region CFA10q26, which is homologous to human chromosome region HSA2p13-21. A comparative map between CFA10q21-26 and HSA2p13-21 was constructed by using genes already localized to HSA2p13-21. A high-resolution radiation map of CFA10q21-26 was constructed to facilitate positional cloning of the CT gene. For this map, seven Type I and eleven Type II markers were mapped. Using homozygosity mapping, the CT locus could be confined to a 42.3 cR3000 region, between the FH2523 and C10.602 markers. On the basis of a partial BAC contig, it was estimated that 1-cR3000 is equivalent to approximately 210 kb, implying that the CT candidate region is therefore estimated to be about 9 Mb. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Refined genetic and comparative physical mapping of the canine copper toxicosis locus

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Publisher
Springer Journals
Copyright
Copyright © 2000 by Springer-Verlag New York Inc.
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003350010086
Publisher site
See Article on Publisher Site

Abstract

Recently, the copper toxicosis (CT) locus in Bedlington terriers was assigned to canine chromosome region CFA10q26, which is homologous to human chromosome region HSA2p13-21. A comparative map between CFA10q21-26 and HSA2p13-21 was constructed by using genes already localized to HSA2p13-21. A high-resolution radiation map of CFA10q21-26 was constructed to facilitate positional cloning of the CT gene. For this map, seven Type I and eleven Type II markers were mapped. Using homozygosity mapping, the CT locus could be confined to a 42.3 cR3000 region, between the FH2523 and C10.602 markers. On the basis of a partial BAC contig, it was estimated that 1-cR3000 is equivalent to approximately 210 kb, implying that the CT candidate region is therefore estimated to be about 9 Mb.

Journal

Mammalian GenomeSpringer Journals

Published: Feb 5, 2014

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