Recently, the copper toxicosis (CT) locus in Bedlington terriers was assigned to canine chromosome region CFA10q26, which is homologous to human chromosome region HSA2p13-21. A comparative map between CFA10q21-26 and HSA2p13-21 was constructed by using genes already localized to HSA2p13-21. A high-resolution radiation map of CFA10q21-26 was constructed to facilitate positional cloning of the CT gene. For this map, seven Type I and eleven Type II markers were mapped. Using homozygosity mapping, the CT locus could be confined to a 42.3 cR3000 region, between the FH2523 and C10.602 markers. On the basis of a partial BAC contig, it was estimated that 1-cR3000 is equivalent to approximately 210 kb, implying that the CT candidate region is therefore estimated to be about 9 Mb.
Mammalian Genome – Springer Journals
Published: Feb 5, 2014
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