Bone Marrow Transplantation (2018) 53:361–365 https://doi.org/10.1038/s41409-017-0053-9 CORRESPONDENCE Reduction of severe acute graft-versus-host disease using a combination of pre transplant anti-thymocyte globulin and post-transplant cyclophosphamide in matched unrelated donor transplantation 1 2 1 1 1 ● ● ● ● ● Uday Deotare Eshetu G. Atenafu David Loach Fotios V. Michelis Dennis (Dong-Hwan) Kim 1 1 1 1 ● ● ● Santhosh Thyagu Jeffrey H. Lipton Hans A. Messner Auro Viswabandya Received: 2 May 2017 / Revised: 6 October 2017 / Accepted: 23 October 2017 / Published online: 21 December 2017 © Macmillan Publishers Limited, part of Springer Nature 2018 Use of Post-transplant Cyclophosphamide (PTCy) has associated with severe forms of GVHD. Here we present recently been introduced speciﬁcally in the haplo-identical the preliminary outcome in our unrelated patients using transplant setting with promising results . This inter- this regimen. vention has also shown a signiﬁcant reduction of acute This is a retrospective study of the patient cohort treated graft versus host disease (aGVHD) and a trend towards from 1 October 2015 until 31 March 2016 in a single center. improving chronic graft versus host disease (cGVHD) . This study was approved by the institutional Research The efﬁcacy of PTCy has
Bone Marrow Transplantation – Springer Journals
Published: Dec 21, 2017
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