Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia in patients older than 50years of age: a systematic review and meta-analysis

Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for... J Cancer Res Clin Oncol (2017) 143:1853–1864 DOI 10.1007/s00432-017-2429-z ORIGINAL ARTICLE – CLINICAL ONCOLOGY Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia in patients older than 50 years of age: a systematic review and meta‑analysis 1,3 1,3 2,3 2,3 2,3 Zhi‑hui Zhang · Xin‑yue Lian · Dong‑ming Yao · Pin‑fang He · Ji‑chun Ma · 2,3 2,3 1,3 2,3 1,3 Zi‑jun Xu · Hong Guo · Wei Zhang · Jiang Lin · Jun Qian Received: 3 January 2017 / Accepted: 18 April 2017 / Published online: 3 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract significantly statistical difference achieved between Purpose A systematic review and meta-analysis were MDS and AML patients in 1-year EFS and NRM [rela- performed to explore the efficacy and safety of allogeneic tive risk (RR) 0.91, 95% CI 0.80–1.04; P = 0.172 and RR hematopoietic stem cell transplantation with a reduced 1.18, 95% CI 0.82–1.69; P = 0.365]. The patients with intensity conditioning regimen in elderly patients with lower diseases risk had the possibility of higher OS rate myelodysplastic syndrome (MDS) or acute myeloid leuke- at ≥ 3 years than those with higher diseases risk (RR 1.37, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Research and Clinical Oncology Springer Journals

Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia in patients older than 50years of age: a systematic review and meta-analysis

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Oncology; Cancer Research; Internal Medicine; Hematology
ISSN
0171-5216
eISSN
1432-1335
D.O.I.
10.1007/s00432-017-2429-z
Publisher site
See Article on Publisher Site

Abstract

J Cancer Res Clin Oncol (2017) 143:1853–1864 DOI 10.1007/s00432-017-2429-z ORIGINAL ARTICLE – CLINICAL ONCOLOGY Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia in patients older than 50 years of age: a systematic review and meta‑analysis 1,3 1,3 2,3 2,3 2,3 Zhi‑hui Zhang · Xin‑yue Lian · Dong‑ming Yao · Pin‑fang He · Ji‑chun Ma · 2,3 2,3 1,3 2,3 1,3 Zi‑jun Xu · Hong Guo · Wei Zhang · Jiang Lin · Jun Qian Received: 3 January 2017 / Accepted: 18 April 2017 / Published online: 3 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract significantly statistical difference achieved between Purpose A systematic review and meta-analysis were MDS and AML patients in 1-year EFS and NRM [rela- performed to explore the efficacy and safety of allogeneic tive risk (RR) 0.91, 95% CI 0.80–1.04; P = 0.172 and RR hematopoietic stem cell transplantation with a reduced 1.18, 95% CI 0.82–1.69; P = 0.365]. The patients with intensity conditioning regimen in elderly patients with lower diseases risk had the possibility of higher OS rate myelodysplastic syndrome (MDS) or acute myeloid leuke- at ≥ 3 years than those with higher diseases risk (RR 1.37,

Journal

Journal of Cancer Research and Clinical OncologySpringer Journals

Published: May 3, 2017

References

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