J Cancer Res Clin Oncol (2017) 143:1853–1864 DOI 10.1007/s00432-017-2429-z ORIGINAL ARTICLE – CLINICAL ONCOLOGY Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia in patients older than 50 years of age: a systematic review and meta‑analysis 1,3 1,3 2,3 2,3 2,3 Zhi‑hui Zhang · Xin‑yue Lian · Dong‑ming Yao · Pin‑fang He · Ji‑chun Ma · 2,3 2,3 1,3 2,3 1,3 Zi‑jun Xu · Hong Guo · Wei Zhang · Jiang Lin · Jun Qian Received: 3 January 2017 / Accepted: 18 April 2017 / Published online: 3 May 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract significantly statistical difference achieved between Purpose A systematic review and meta-analysis were MDS and AML patients in 1-year EFS and NRM [rela- performed to explore the efficacy and safety of allogeneic tive risk (RR) 0.91, 95% CI 0.80–1.04; P = 0.172 and RR hematopoietic stem cell transplantation with a reduced 1.18, 95% CI 0.82–1.69; P = 0.365]. The patients with intensity conditioning regimen in elderly patients with lower diseases risk had the possibility of higher OS rate myelodysplastic syndrome (MDS) or acute myeloid leuke- at ≥ 3 years than those with higher diseases risk (RR 1.37,
Journal of Cancer Research and Clinical Oncology – Springer Journals
Published: May 3, 2017
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