Mammalian Genome 9, 905–906 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 hpy Reduced activity of BRAF protein kinase in hop and hop mouse mutants 1 2 3 3 4 Leszek Wojnowski, Ricardo Berna, Cynthia M. Park, Mary Ann Handel, Willard F. Hollander, Andreas Zimmer Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892, USA National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA Emeritus, Department of Genetics, Iowa State University, Ames Iowa 50014, USA Received: 22 January 1998 / Accepted: 10 July 1998 Recent advances in genetic mapping and gene targeting have fa- cilitated the identification of molecular defects for several classic mouse mutants (for example, Balling et al. 1988; D’Arcangelo et al. 1995; Nehls et al. 1994). Two interesting mouse mutants that still await molecular identification are hop and hpy. These are allelic variants (Handel et al. 1985), designated hop (hop-sterile) hpy and hop (hydrocephalic-polydactyl), of a gene localized on hpy mouse Chromosome (Chr) 6 at 13.0 cM (Lyon 1973). Hop was found in 1964 among descendants of mice exposed to ionizing radiation (Hollander 1976),
Mammalian Genome – Springer Journals
Published: Nov 1, 1998
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