Recrystallization and Water Absorption Properties of Vitrified Trehalose Near Room Temperature

Recrystallization and Water Absorption Properties of Vitrified Trehalose Near Room Temperature Pharm Res (2018) 35: 139 https://doi.org/10.1007/s11095-018-2420-7 RESEARCH PAPER Recrystallization and Water Absorption Properties of Vitrified Trehalose Near Room Temperature 1 1 Ryo Shirakashi & Kiyoshi Takano Received: 19 December 2017 /Accepted: 29 April 2018 /Published online: 10 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT ABBREVIATIONS Purpose To provide the physicochemical properties of vitri- V Molar volume of water, (= 18 mL/mol) fied trehalose for predicting its recrystallization. V Partial molar volume of trehalose (= 211 mL/mol) trh Methods Thin films of vitrified trehalose solutions were pre- △μ Chemical potential difference of water from the stan- pared at room temperature and exposed to various humid dard state, μ -μ w w and temperature atmospheres. The in-situ amount of retained μ Chemical potential, J/mol water in the vacuum-dried trehalose thin film during exposure φ Volume fraction of water (ratio of the volume occupied was determined using its FTIR spectrum by quantifying the by water in the total volume of the solution) extremely infinitesimal amount of retained water in the treha- A Water activity of the desiccated trehalose film lose solution. Recrystallization of the sample was also assessed c Molar fraction of solute −23 by the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmaceutical Research Springer Journals

Recrystallization and Water Absorption Properties of Vitrified Trehalose Near Room Temperature

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering
ISSN
0724-8741
eISSN
1573-904X
D.O.I.
10.1007/s11095-018-2420-7
Publisher site
See Article on Publisher Site

Abstract

Pharm Res (2018) 35: 139 https://doi.org/10.1007/s11095-018-2420-7 RESEARCH PAPER Recrystallization and Water Absorption Properties of Vitrified Trehalose Near Room Temperature 1 1 Ryo Shirakashi & Kiyoshi Takano Received: 19 December 2017 /Accepted: 29 April 2018 /Published online: 10 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT ABBREVIATIONS Purpose To provide the physicochemical properties of vitri- V Molar volume of water, (= 18 mL/mol) fied trehalose for predicting its recrystallization. V Partial molar volume of trehalose (= 211 mL/mol) trh Methods Thin films of vitrified trehalose solutions were pre- △μ Chemical potential difference of water from the stan- pared at room temperature and exposed to various humid dard state, μ -μ w w and temperature atmospheres. The in-situ amount of retained μ Chemical potential, J/mol water in the vacuum-dried trehalose thin film during exposure φ Volume fraction of water (ratio of the volume occupied was determined using its FTIR spectrum by quantifying the by water in the total volume of the solution) extremely infinitesimal amount of retained water in the treha- A Water activity of the desiccated trehalose film lose solution. Recrystallization of the sample was also assessed c Molar fraction of solute −23 by the

Journal

Pharmaceutical ResearchSpringer Journals

Published: May 10, 2018

References

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