Pharm Res (2018) 35: 139 https://doi.org/10.1007/s11095-018-2420-7 RESEARCH PAPER Recrystallization and Water Absorption Properties of Vitrified Trehalose Near Room Temperature 1 1 Ryo Shirakashi & Kiyoshi Takano Received: 19 December 2017 /Accepted: 29 April 2018 /Published online: 10 May 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 ABSTRACT ABBREVIATIONS Purpose To provide the physicochemical properties of vitri- V Molar volume of water, (= 18 mL/mol) fied trehalose for predicting its recrystallization. V Partial molar volume of trehalose (= 211 mL/mol) trh Methods Thin films of vitrified trehalose solutions were pre- △μ Chemical potential difference of water from the stan- pared at room temperature and exposed to various humid dard state, μ -μ w w and temperature atmospheres. The in-situ amount of retained μ Chemical potential, J/mol water in the vacuum-dried trehalose thin film during exposure φ Volume fraction of water (ratio of the volume occupied was determined using its FTIR spectrum by quantifying the by water in the total volume of the solution) extremely infinitesimal amount of retained water in the treha- A Water activity of the desiccated trehalose film lose solution. Recrystallization of the sample was also assessed c Molar fraction of solute −23 by the
Pharmaceutical Research – Springer Journals
Published: May 10, 2018
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