Short Communications Incorporating Mouse Genome Mammalian Genome 12, 318–322 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s003350020005 Recombination is proportional to the number of chromosome arms in mammals 1, 1,2 Fernando Pardo-Manuel de Villena, * Carmen Sapienza Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA Received: 24 October 2000 / Accepted: 5 December, 2000 In sexually reproducing organisms recombination contributes sig- the selective force resulting in sex and recombination; the Red nificantly to the processes of DNA repair, fidelity of chromosome Queen and the Tangled Bank (Maynard Smith 1978; Bell 1982; segregation, and generation of genetic diversity. Abnormal recom- Charlesworth 1985). The Red Queen hypothesis proposes that re- bination is associated with decreased fitness of offspring, aneu- combination is selected to counter the antagonistic advances made ploidy, and several human diseases (Chaganti et al. 1974; Charles- by the biotic environment, particularly parasites, during the previ- worth and Barton 1996; Hassold et al. 2000). Despite its impor- ous generations. This hypothesis predicts that recombination is tance, little is known of how the rate and pattern
Mammalian Genome – Springer Journals
Published: Feb 27, 2001
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