Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial

Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in... J Endocrinol Invest (2018) 41:475–483 https://doi.org/10.1007/s40618-017-0786-8 ORIGINAL ARTICLE Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial 1 2 3 4 5 6 7 J. Kim  · B.‑K. Suh  · C. W. Ko  · K.‑H. Lee  · C. H. Shin  · J. S. Hwang  · H. S. Kim  · 8 9 10 11 1 12 W. Y. Chung  · C. J. Kim  · H.‑S. Han  · N. Y. Kwon  · S. Y. Cho  · H.‑W. Yoo  · D.‑K. Jin   Received: 13 July 2017 / Accepted: 25 October 2017 / Published online: 4 November 2017 © The Author(s) 2017. This article is an open access publication Abstract 0.63 ± 0.16 and 0.64 ± 0.46, respectively, for the treatment Purpose Several studies have evaluated the effects of group, and 0.06 ± 0.15 and 0.06 ± 0.28, respectively, for the growth hormone (GH) on auxological and biochemical control group (p < 0.001). Serum insulin-like growth fac- parameters in children with non-GH-deficient, idiopathic tor (IGF-1) and insulin-like growth factor binding protein-3 short stature (ISS). This study evaluated the efficacy and (IGFBP-3) increased significantly in the treatment group at safety of Gr owtropin -II (recombinant human GH) in week 26 compared to baseline. However, the SDS for body Korean patients with ISS. mass index (BMI) at 26 weeks did not change significantly Methods This was a 1-year, open-label, multicenter, phase in either http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinological Investigation Springer Journals

Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Medicine/Public Health, general; Endocrinology; Metabolic Diseases
eISSN
1720-8386
D.O.I.
10.1007/s40618-017-0786-8
Publisher site
See Article on Publisher Site

Abstract

J Endocrinol Invest (2018) 41:475–483 https://doi.org/10.1007/s40618-017-0786-8 ORIGINAL ARTICLE Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial 1 2 3 4 5 6 7 J. Kim  · B.‑K. Suh  · C. W. Ko  · K.‑H. Lee  · C. H. Shin  · J. S. Hwang  · H. S. Kim  · 8 9 10 11 1 12 W. Y. Chung  · C. J. Kim  · H.‑S. Han  · N. Y. Kwon  · S. Y. Cho  · H.‑W. Yoo  · D.‑K. Jin   Received: 13 July 2017 / Accepted: 25 October 2017 / Published online: 4 November 2017 © The Author(s) 2017. This article is an open access publication Abstract 0.63 ± 0.16 and 0.64 ± 0.46, respectively, for the treatment Purpose Several studies have evaluated the effects of group, and 0.06 ± 0.15 and 0.06 ± 0.28, respectively, for the growth hormone (GH) on auxological and biochemical control group (p < 0.001). Serum insulin-like growth fac- parameters in children with non-GH-deficient, idiopathic tor (IGF-1) and insulin-like growth factor binding protein-3 short stature (ISS). This study evaluated the efficacy and (IGFBP-3) increased significantly in the treatment group at safety of Gr owtropin -II (recombinant human GH) in week 26 compared to baseline. However, the SDS for body Korean patients with ISS. mass index (BMI) at 26 weeks did not change significantly Methods This was a 1-year, open-label, multicenter, phase in either

Journal

Journal of Endocrinological InvestigationSpringer Journals

Published: Nov 4, 2017

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