Recent synthetic scenario on imidazo[1,2-a]pyridines
Selvaraj Mohana Roopan
Shashikant Malagoud Patil
Received: 3 June 2015 / Accepted: 6 August 2015 / Published online: 21 August 2015
Ó Springer Science+Business Media Dordrecht 2015
Abstract Of the biologically important benzene fused heterocycles, the most
important are those containing a ring-junction nitrogen. The majority of ring junction
systems do not occur naturally, but they have been important from a theoretical
viewpoint, for preparation of potentially active analogues. The imidazo[1,2-a]
pyridines are an important class of nitrogen ring junction heterocyclic compounds.
They have huge applications in medicinal chemistry and drug molecule production.
Thus, the initial discussion focuses on synthetic strategies of imidazo[1,2-a] pyridines,
and later we disclose the reactivity of the imidazo[1,2-a]pyridines. This review is
intended to summarize and discuss the most recent developments of synthesis and
reactivity of imidazo[1,2-a]pyridines, mainly the contributions after 2007.
Keywords Heterocycles Á Imidazole Á Pyridine Á Fused ring junction compounds Á
Heterocyclic chemistry has been a part of intense research in medicinal and
biological companies . There has been an effort to design, synthesize and exploit
unreported heterocyclic scaffolds for therapeutic applications . Use of a
heteroatom, especially nitrogen, as a bridgehead atom is being evaluated extensively
so as to come up with novel heterocycles for therapeutic use.
The enormous category of these systems does not occur naturally, but these
systems have been the subject of many studies. Nitrogen-bridgehead-fused
& Selvaraj Mohana Roopan
Chemistry of Heterocycles and Natural Product Research Laboratory, Organic Chemistry
Division, School of Advanced Sciences, VIT University, Vellore, Tamilnadu 632 014, India
Res Chem Intermed (2016) 42:2749–2790