Recent synthetic approaches to fipronil, a super-effective and safe pesticide

Recent synthetic approaches to fipronil, a super-effective and safe pesticide Pesticide & Aamer Saeed Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan 123 6806 A. Saeed et al. Keywords Fipronil  Pyrazole parasiticide Introduction Phenyl pyrazoles show a wide range of biological activities [1]. Fipronil (5-amino- 1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4-trifluoromethyl sulfinyl-lH- pyrazole- 3-carbonitrile) (1) is a phenyl pyrazole containing six fluorine and two chlorine atoms and a cyano substituent (Fig. 1). It is effective against a host of crop insect pests, including grasshoppers, boll weevils, rice insects, termites, house flies, fruit flies, and thrips [2]. The literature is replete with reports of the pesticidal activity of fipronil [3, 4], a highly effective broad-spectrum insecticide widely used for fruits, vegetables, coffee, rice, and other crops, as well as for seed treatment and soil injection [5, 6]. It is registered for use by lawn care and pest control operators to treat golf courses and food-handling establishments. These features of fipronil prompted us to review its recent synthetic applications, for which we surveyed the literature from 2005 to the present. Many patents have been published recently describing the synthesis of fipronil at length. Moreover, various synthetic analogs have been created to examine its bioactivity. A key step involved in the synthesis of fipronil is Research on Chemical Intermediates Springer Journals

Recent synthetic approaches to fipronil, a super-effective and safe pesticide

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial