Recent synthetic approaches to fipronil, a super-effective and safe pesticide

Recent synthetic approaches to fipronil, a super-effective and safe pesticide Pesticide & Aamer Saeed aamersaeed@yahoo.com Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan 123 6806 A. Saeed et al. Keywords Fipronil  Pyrazole parasiticide Introduction Phenyl pyrazoles show a wide range of biological activities [1]. Fipronil (5-amino- 1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4-trifluoromethyl sulfinyl-lH- pyrazole- 3-carbonitrile) (1) is a phenyl pyrazole containing six fluorine and two chlorine atoms and a cyano substituent (Fig. 1). It is effective against a host of crop insect pests, including grasshoppers, boll weevils, rice insects, termites, house flies, fruit flies, and thrips [2]. The literature is replete with reports of the pesticidal activity of fipronil [3, 4], a highly effective broad-spectrum insecticide widely used for fruits, vegetables, coffee, rice, and other crops, as well as for seed treatment and soil injection [5, 6]. It is registered for use by lawn care and pest control operators to treat golf courses and food-handling establishments. These features of fipronil prompted us to review its recent synthetic applications, for which we surveyed the literature from 2005 to the present. Many patents have been published recently describing the synthesis of fipronil at length. Moreover, various synthetic analogs have been created to examine its bioactivity. A key step involved in the synthesis of fipronil is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Recent synthetic approaches to fipronil, a super-effective and safe pesticide

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2527-6
Publisher site
See Article on Publisher Site

Abstract

Pesticide & Aamer Saeed aamersaeed@yahoo.com Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan 123 6806 A. Saeed et al. Keywords Fipronil  Pyrazole parasiticide Introduction Phenyl pyrazoles show a wide range of biological activities [1]. Fipronil (5-amino- 1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4-trifluoromethyl sulfinyl-lH- pyrazole- 3-carbonitrile) (1) is a phenyl pyrazole containing six fluorine and two chlorine atoms and a cyano substituent (Fig. 1). It is effective against a host of crop insect pests, including grasshoppers, boll weevils, rice insects, termites, house flies, fruit flies, and thrips [2]. The literature is replete with reports of the pesticidal activity of fipronil [3, 4], a highly effective broad-spectrum insecticide widely used for fruits, vegetables, coffee, rice, and other crops, as well as for seed treatment and soil injection [5, 6]. It is registered for use by lawn care and pest control operators to treat golf courses and food-handling establishments. These features of fipronil prompted us to review its recent synthetic applications, for which we surveyed the literature from 2005 to the present. Many patents have been published recently describing the synthesis of fipronil at length. Moreover, various synthetic analogs have been created to examine its bioactivity. A key step involved in the synthesis of fipronil is

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 4, 2016

References

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