Special Section: Genetics of Alcohol-related Traits Incorporating Mouse Genome Mammalian Genome 9, 927–928 (1998). © Springer-Verlag New York Inc. 1998 Recent progress toward the identification of genes related to risk for alcoholism Kari J. Buck Department of Behavioral Neuroscience and Alcohol Research Center, Oregon Health Sciences University, and Department of Veterans Affairs Medical Center, R&D40, 3710 SW US Veterans Hospital Road, Portland, Oregon 97201, USA Received: 15 September 1998 / Accepted: 8 October 1998 It is estimated that 40–60% of the risk for developing alcohol consumption QTLs on Chrs 1, 4, and 9 that show partial or com- dependence (alcoholism) is explained by genetic factors (Schuckit plete B6 allele dominance (Tarantino et al. 1998; Phillips et al., 1994). However, the multiple genes or quantitative trait loci this issue). The B6 backcross strategy is likely to miss QTLs (QTLs) involved remain to be characterized. Progress toward the showing partial or complete dominance for the B6 allele and, not identification of specific genes related to risk for alcoholism has surprisingly, did not detect these QTLs. been slow owing in part to phenotypic heterogeneity, genetic het- Overlapping regions of Chrs 1 and 2 have also been confirmed erogeneity, and gene-environment interactions. Given
Mammalian Genome – Springer Journals
Published: Dec 1, 1998
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