Breast Cancer Res Treat (2017) 165:285–291 DOI 10.1007/s10549-017-4320-7 REVIEW Reassessing risk models for atypical hyperplasia: age may not matter 1 2 2 5 • • • • Emanuele Mazzola Suzanne B. Coopey Molly Grifﬁn Fernanda Polubriaginof 6 1 3 2 • • • • Julliette M. Buckley Giovanni Parmigiani Judy E. Garber Barbara L. Smith 2 2 4 2 • • • Michele A. Gadd Michelle C. Specht Anthony Guidi Kevin S. Hughes Received: 23 May 2017 / Accepted: 27 May 2017 / Published online: 6 June 2017 Springer Science+Business Media New York 2017 Abstract Results For all atypia diagnoses combined, our cohort Purpose The aim of this study was to investigate the showed a 5-, 10-, and 15-year risk of invasive breast cancer inﬂuence of age at diagnosis of atypical hyperplasia or DCIS of 0.56, 1.25, and 1.30, respectively, with no (‘‘atypia’’, ductal [ADH], lobular [ALH], or severe ADH) signiﬁcant difference in the (65,75] year age group. For on the risk of developing subsequent invasive breast cancer women aged (35,75] years, we observed no signiﬁcant or ductal carcinoma in situ (DCIS). difference in the 15-year risk of invasive breast cancer or Methods Using standard survival analysis methods, we
Breast Cancer Research and Treatment – Springer Journals
Published: Jun 6, 2017
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