Breast Cancer Res Treat (2018) 168:17–27 https://doi.org/10.1007/s10549-017-4508-x PRECLINICAL STUDY Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer 1 2 2 3 • • • • Joseﬁne Bostner Anya Alayev Adi Y. Berman Tommy Fornander 1 2,4,5 1 • • Bo Nordenskjo¨ld Marina K. Holz Olle Sta˚l Received: 31 May 2017 / Accepted: 12 September 2017 / Published online: 11 November 2017 The Author(s) 2017. This article is an open access publication Abstract localization in ERa-positive cell lines was compared with Purpose Deregulated PI3K/mTOR signals can promote the that in ERa-negative cell lines. growth of breast cancer and contribute to endocrine treat- Results Raptor protein expression in the nucleus was high ment resistance. This report aims to investigate raptor and in ER/PgR-positive and HER2-negative tumors with low its intracellular localization to further understand its role in grade, features associated with the luminal A subtype. ER-positive breast cancer. Presence of raptor in the nucleus was connected with ERa Methods Raptor protein expression was evaluated by signaling, here shown by a coupled increase of ERa immunohistochemistry in 756 primary breast tumors from phosphorylation at S167 and S305 with accumulation of postmenopausal patients randomized to tamoxifen or no nuclear
Breast Cancer Research and Treatment – Springer Journals
Published: Nov 11, 2017
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