Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer

Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive... Breast Cancer Res Treat (2018) 168:17–27 https://doi.org/10.1007/s10549-017-4508-x PRECLINICAL STUDY Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer 1 2 2 3 • • • • Josefine Bostner Anya Alayev Adi Y. Berman Tommy Fornander 1 2,4,5 1 • • Bo Nordenskjo¨ld Marina K. Holz Olle Sta˚l Received: 31 May 2017 / Accepted: 12 September 2017 / Published online: 11 November 2017 The Author(s) 2017. This article is an open access publication Abstract localization in ERa-positive cell lines was compared with Purpose Deregulated PI3K/mTOR signals can promote the that in ERa-negative cell lines. growth of breast cancer and contribute to endocrine treat- Results Raptor protein expression in the nucleus was high ment resistance. This report aims to investigate raptor and in ER/PgR-positive and HER2-negative tumors with low its intracellular localization to further understand its role in grade, features associated with the luminal A subtype. ER-positive breast cancer. Presence of raptor in the nucleus was connected with ERa Methods Raptor protein expression was evaluated by signaling, here shown by a coupled increase of ERa immunohistochemistry in 756 primary breast tumors from phosphorylation at S167 and S305 with accumulation of postmenopausal patients randomized to tamoxifen or no nuclear http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Research and Treatment Springer Journals

Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer

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Publisher
Springer Journals
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Oncology
ISSN
0167-6806
eISSN
1573-7217
D.O.I.
10.1007/s10549-017-4508-x
Publisher site
See Article on Publisher Site

Abstract

Breast Cancer Res Treat (2018) 168:17–27 https://doi.org/10.1007/s10549-017-4508-x PRECLINICAL STUDY Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer 1 2 2 3 • • • • Josefine Bostner Anya Alayev Adi Y. Berman Tommy Fornander 1 2,4,5 1 • • Bo Nordenskjo¨ld Marina K. Holz Olle Sta˚l Received: 31 May 2017 / Accepted: 12 September 2017 / Published online: 11 November 2017 The Author(s) 2017. This article is an open access publication Abstract localization in ERa-positive cell lines was compared with Purpose Deregulated PI3K/mTOR signals can promote the that in ERa-negative cell lines. growth of breast cancer and contribute to endocrine treat- Results Raptor protein expression in the nucleus was high ment resistance. This report aims to investigate raptor and in ER/PgR-positive and HER2-negative tumors with low its intracellular localization to further understand its role in grade, features associated with the luminal A subtype. ER-positive breast cancer. Presence of raptor in the nucleus was connected with ERa Methods Raptor protein expression was evaluated by signaling, here shown by a coupled increase of ERa immunohistochemistry in 756 primary breast tumors from phosphorylation at S167 and S305 with accumulation of postmenopausal patients randomized to tamoxifen or no nuclear

Journal

Breast Cancer Research and TreatmentSpringer Journals

Published: Nov 11, 2017

References

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