Rafts as Missing Link between Multidrug Resistance and Sphingolipid Metabolism

Rafts as Missing Link between Multidrug Resistance and Sphingolipid Metabolism J. Membrane Biol. 203, 57–64 (2005) DOI: 10.1007/s00232-004-0733-4 Topical Review J.W.J. Hinrichs, K. Klappe, J.W. Kok Groningen University Institute for Drug Exploration, Department of Membrane Cell Biology, University of Groningen, 9713 AV Groningen, The Netherlands Received: 30 September 2004/Revised: 20 December 2004 Introduction Multidrug Resistance, Sphingolipids and ATP-binding Cassette Transporters Since their discovery, detergent-insoluble glyco- sphingolipid-enriched membrane domains have ac- Chemotherapy is the primary approach towards the counted for several cellular functions. Besides their treatment of metastatic cancers. While initially tumor role in protein and lipid transport in polarized cells, cells can respond well to treatment with chemother- most of the attention focuses on their organizing role apeutic agents, repeated drug administration often in signal transduction. Given that virtually all mul- results in the selection of drug-resistant cells, and tidrug-resistant cells exhibit a deviating sphingolipid hence in incurable relapses. Very often these cells do composition, most typically increased levels of glu- not only gain resistance to the initially applied drugs, cosylceramide, a possible role of sphingolipids in but also to a variety of (structurally unrelated) che- multidrug-resistance has been investigated. An in- motherapeutic agents, a feature called multidrug- creased conversion of cytotoxic drug-induced cera- resistance [37]. Regarding the lipid http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Rafts as Missing Link between Multidrug Resistance and Sphingolipid Metabolism

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Copyright © 2005 by Springer Science+Business Media, Inc.
Life Sciences; Human Physiology; Biochemistry, general
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