Ir J Med Sci (2017) 186:647–652 DOI 10.1007/s11845-016-1542-3 ORIGINAL ARTICLE Radiotherapy for the treatment of thyroid eye disease—a prospective comparison: Is orbital radiotherapy a suitable alternative to steroids? 1 1 2 3 1 • • • • P. Grassi D. Strianese R. Piscopo R. Pacelli G. Bonavolonta ` Received: 6 June 2016 / Accepted: 25 December 2016 / Published online: 3 January 2017 Royal Academy of Medicine in Ireland 2017 Abstract considered a suitable alternative treatment in TED for Background and aims To evaluate the efﬁcacy of orbital patients who cannot tolerate steroids. radiotherapy (OR) for the treatment of thyroid eye disease (TED). Keywords Alternative ﬁrst-line therapy Graves Methods Thirty-ﬁve consecutive patients with active TED ophthalmopathy Orbital radiotherapy Thyroid eye with contraindications to steroid therapy received a course disease of OR. Bilateral retrobulbar irradiation was performed with a total dose of 20 Gy. 7-points clinical activity score (7- CAS), ocular motility, visual acuity (VA), exophthalmos Introduction and eyelid retraction were prospectively evaluated at 3, 6 and 12 months and compared with baseline data. Thyroid eye disease (TED) is an autoimmune disease Results There was a statistically signiﬁcant improvement involving the retro-ocular and peri-ocular tissues associ- in
Irish Journal of Medical Science (1971 -) – Springer Journals
Published: Jan 3, 2017
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