J Radiat Oncol (2017) 6:287–294 DOI 10.1007/s13566-017-0302-y ORIGINAL RESEARCH Radiographic predictors of response to endoluminal brachytherapy for the treatment of rectal cancer 1 2 2 3 Rebecca Craig-Schapiro & Ihab R. Kamel & Michael Sacerdote & Joseph Canner & 4 1 5 6 Meredith Pittman & Caitlin W. Hicks & Amy Hacker-Prietz & Robert F. Hobbs & 6 1 1 5 Elwood P. Armour & Jonathan E. Efron & Elizabeth C. Wick & Nilofer S. Azad & 5,6 1 Joseph M. Herman & Susan L. Gearhart Received: 13 October 2016 /Accepted: 15 March 2017 /Published online: 30 March 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract tumor volume on MRI than did CRT (92.7% vs. 63.1%, Objective Endoluminal brachytherapy (EBT) has been shown p = 0.004). Using receiver operating characteristic analysis, to be an effective neoadjuvant monotherapy for rectal adeno- change in peak standardized uptake value was the best predic- carcinoma. Radiographic predictors of response are used to tor for complete pathologic response in EBT patients (sensi- guide treatment in rectal cancer; however, no predictors of tivity 67%, specificity 82%). False-positive findings for nodal response to EBT have been identified. disease on MRI were seen in 59% of EBT patients and
Journal of Radiation Oncology – Springer Journals
Published: Mar 30, 2017
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