J Radiat Oncol (2017) 6:265–272 DOI 10.1007/s13566-017-0299-2 ORIGINAL RESEARCH Radiation therapy for localized malignant pleural mesothelioma: a propensity score-matched analysis of the National Cancer Data Base 1 2,3,4 2,3 4 5 Nisha Ohri & Emanuela Taioli & Bian Liu & Andrea Wolf & Jorge Gomez & 4 1 Raja Flores & Kenneth E. Rosenzweig Received: 20 December 2016 /Accepted: 3 March 2017 /Published online: 11 March 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract 5.3%, respectively; p < 0.001). In multivariable analysis and Objective The objectives of this study were to analyze rates of propensity matched analysis, definitive RT was significantly radiation therapy (RT) utilization for malignant pleural meso- associated with improved survival (adjusted hazard ratio [adj thelioma (MPM) and evaluate the association between RT and HR] 0.78, 95% CI 0.70–0.87) and (adj HR 0.77, 95% CI overall survival (OS). 0.67–0.89), respectively. Compared to no therapy, surgery Methods The National Cancer Data Base (NCDB) was que- and RT (adj HR 0.41, 95% CI 0.31–0.54) and trimodality ried to identify patients with non-metastatic MPM diagnosed therapy (adj HR 0.47, 95% CI 0.40–0.55) were associated between 2004 and 2013. RT was defined as receipt of 40- with the best survival. 65Gy of external
Journal of Radiation Oncology – Springer Journals
Published: Mar 11, 2017
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