Objective The negative effects of incidental radiation on the detected by 16 weeks after radiation. Soy isoflavones given heart and its vessels, particularly in the treatment of locally in conjunction with thoracic irradiation were found to reduce advanced non-small cell lung cancer, esophageal cancer, left- damage to the artery walls and radiation-induced fibrosis in sided breast cancer, and lymphoma, are known. Late cardiac the myocardium. events induced by radiotherapy including coronary artery dis- Conclusion Our histopathological findings suggest a radio- protective role of soy isoflavones to prevent cardiac injury. ease, ischemia, congestive heart failure, and myocardial in- farction can manifest months to years after radiotherapy. We This approach could translate to the use of soy isoflavones as a safe complement to thoracic radiotherapy with the goal have previously demonstrated that soy isoflavones mitigate inflammatory responses induced in lungs by thoracic irradia- of improving the overall survival in patients whose cancer has been successfully controlled by the radiotherapy but who oth- tion resulting in decreased vascular damage, inflammation, and fibrosis. In the current study, we investigate the use of erwise succumb to heart toxicity. soy isoflavones to protect cardiac vessels and myocardium . . . from radiation injury. Keywords Radiation
Journal of Radiation Oncology – Springer Journals
Published: Mar 22, 2017
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