Quantitative sodium imaging and gliomas: a feasibility study

Quantitative sodium imaging and gliomas: a feasibility study Purpose Recent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical applica- tion. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measure- ments to evaluate gliomas. 1 23 H/ Na head coil, generating maps Methods Eight patients with treatment-naïve gliomas were scanned at 3 T with a homemade of pseudo-intracellular sodium concentration (C ), pseudo-extracellular volume fraction (α ), apparent intracellular sodium 1 2 concentration (aISC), and apparent total sodium concentration (aTSC). Measurements were made within the contralateral normal-appearing putamen, contralateral normal-appearing white matter (NAWM), and solid tumor regions (area of T2- FLAIR abnormality, excluding highly likely areas of edema, cysts, or necrosis). Paired samples t test were performed comparing NAWM and putamen and between NAWM and solid tumor. Results The normal-appearing putamen demonstrated significantly higher values for aTSC, aISC, C (p < 0.001), and α (p = 1 2 0.002) when compared to those of NAWM. The mean average http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroradiology 0028-3940 Springer Journals
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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Neuroradiology; Imaging / Radiology; Neurology; Neurosurgery; Neurosciences
ISSN
0028-3940
eISSN
1432-1920
D.O.I.
10.1007/s00234-018-2041-1
Publisher site
See Article on Publisher Site

Abstract

Purpose Recent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical applica- tion. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measure- ments to evaluate gliomas. 1 23 H/ Na head coil, generating maps Methods Eight patients with treatment-naïve gliomas were scanned at 3 T with a homemade of pseudo-intracellular sodium concentration (C ), pseudo-extracellular volume fraction (α ), apparent intracellular sodium 1 2 concentration (aISC), and apparent total sodium concentration (aTSC). Measurements were made within the contralateral normal-appearing putamen, contralateral normal-appearing white matter (NAWM), and solid tumor regions (area of T2- FLAIR abnormality, excluding highly likely areas of edema, cysts, or necrosis). Paired samples t test were performed comparing NAWM and putamen and between NAWM and solid tumor. Results The normal-appearing putamen demonstrated significantly higher values for aTSC, aISC, C (p < 0.001), and α (p = 1 2 0.002) when compared to those of NAWM. The mean average

Journal

Neuroradiology 0028-3940Springer Journals

Published: Jun 3, 2018

References

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