Purpose Recent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical applica- tion. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measure- ments to evaluate gliomas. 1 23 H/ Na head coil, generating maps Methods Eight patients with treatment-naïve gliomas were scanned at 3 T with a homemade of pseudo-intracellular sodium concentration (C ), pseudo-extracellular volume fraction (α ), apparent intracellular sodium 1 2 concentration (aISC), and apparent total sodium concentration (aTSC). Measurements were made within the contralateral normal-appearing putamen, contralateral normal-appearing white matter (NAWM), and solid tumor regions (area of T2- FLAIR abnormality, excluding highly likely areas of edema, cysts, or necrosis). Paired samples t test were performed comparing NAWM and putamen and between NAWM and solid tumor. Results The normal-appearing putamen demonstrated significantly higher values for aTSC, aISC, C (p < 0.001), and α (p = 1 2 0.002) when compared to those of NAWM. The mean average
Neuroradiology 0028-3940 – Springer Journals
Published: Jun 3, 2018
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