Quantitative relationship of renal blood flow with size and density of glomeruli in rat postnatal ontogenesis

Quantitative relationship of renal blood flow with size and density of glomeruli in rat postnatal... The aim of the study was to find the quantitative relationship of postnatal changes in the glomeruli anatomic structure with the blood flow in kidneys. Kidney development was studied in 4-, 12-, 30-, and 65-day-old Wistar rats. Diameters of glomerulus (Dgl, μm), afferent and efferent arterioles (Daf and Def), and the glomeruli density (Ngl/mm−3) were measured posthumously. Volumes of one (Ugl, μm3) and all glomeruli (ΣUgl, mm3/cm3) and the glomeruli arterioles lumen (Saf, Sef, μm2) were calculated. The renal specific blood flow (SBF per unit of kidney weight, KW, mg) was measured by the laser-Doppler flowmeter (in perfusion units, p.u.) under sodium barbamyl narcosis. To assess the relationship of these parameters, we found their allometric association. We have found that, during postnatal growth, glomeruli morphological parameters vary according to the equations: Dgl = 7.1□KW0.41, Ugl = 187□KW1.23, Ngl = 5309□KW−0.63 (KW, mg and for one kidney), Saf = 1.1□Ugl0.35, and Sef = 6.3□Ugl0.14. The renal SBF in 4-, 12-, and 65-day-old rats increases according to SBF = 6.7□(ΣUgl)0.98. The renal SBF calculated per unit of glomeruli volume varies a little with age. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Quantitative relationship of renal blood flow with size and density of glomeruli in rat postnatal ontogenesis

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2012 by Pleiades Publishing, Ltd.
Subject
Life Sciences; Developmental Biology; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360412010067
Publisher site
See Article on Publisher Site

Abstract

The aim of the study was to find the quantitative relationship of postnatal changes in the glomeruli anatomic structure with the blood flow in kidneys. Kidney development was studied in 4-, 12-, 30-, and 65-day-old Wistar rats. Diameters of glomerulus (Dgl, μm), afferent and efferent arterioles (Daf and Def), and the glomeruli density (Ngl/mm−3) were measured posthumously. Volumes of one (Ugl, μm3) and all glomeruli (ΣUgl, mm3/cm3) and the glomeruli arterioles lumen (Saf, Sef, μm2) were calculated. The renal specific blood flow (SBF per unit of kidney weight, KW, mg) was measured by the laser-Doppler flowmeter (in perfusion units, p.u.) under sodium barbamyl narcosis. To assess the relationship of these parameters, we found their allometric association. We have found that, during postnatal growth, glomeruli morphological parameters vary according to the equations: Dgl = 7.1□KW0.41, Ugl = 187□KW1.23, Ngl = 5309□KW−0.63 (KW, mg and for one kidney), Saf = 1.1□Ugl0.35, and Sef = 6.3□Ugl0.14. The renal SBF in 4-, 12-, and 65-day-old rats increases according to SBF = 6.7□(ΣUgl)0.98. The renal SBF calculated per unit of glomeruli volume varies a little with age.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Jan 20, 2012

References

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