Quantification of Inter-Erythrocyte Forces with Ultra-High Frequency (410MHz) Single Beam Acoustic Tweezer

Quantification of Inter-Erythrocyte Forces with Ultra-High Frequency (410MHz) Single Beam... Efforts on quantitative measurements of the interactive forces of red blood cells (RBC) have been pursued for many years in hopes of a better understanding of hemodynamics and blood rheology. In this paper, we report an approach based on an ultra-high frequency (410 MHz) single beam acoustic tweezer (SBAT) for quantitative measurements of inter-RBC forces at a single cell level. The trapping forces produced by this ultra-high frequency (UHF) SBAT can be quantitatively estimated with a micropipette. Since the focal beam diameter of the 410 MHz ultrasonic transducer used in this SBAT was only 6.5 micrometer (μm), which was smaller than that of a RBC (~7.5 μm), it was made possible to directly apply the beam to a single RBC and measure inter-RBC forces against the pre-calibrated acoustic trapping forces as another example of potential cellular applications of the SBAT. The magnitude of these forces was found to be 391.0 ± 86.4 pN. Finally, it is worth noting that unlike several other methods, this method does not require the measuring device to be in contact with the cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Biomedical Engineering Springer Journals

Quantification of Inter-Erythrocyte Forces with Ultra-High Frequency (410MHz) Single Beam Acoustic Tweezer

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Publisher
Springer US
Copyright
Copyright © 2017 by Biomedical Engineering Society
Subject
Biomedicine; Biomedicine, general; Biomedical Engineering; Biological and Medical Physics, Biophysics; Classical Mechanics; Biochemistry, general
ISSN
0090-6964
eISSN
1573-9686
D.O.I.
10.1007/s10439-017-1863-z
Publisher site
See Article on Publisher Site

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