Quality of life trajectories during the first year following hematopoietic cell transplantation: an inception cohort study

Quality of life trajectories during the first year following hematopoietic cell transplantation:... Background Allogeneic hematopoietic cell transplantation (HCT) affects quality of life (QOL). Patient-reported outcomes examine symptoms, side effects, distress, and physical and social problems, but positive outcomes have been ignored. This inception cohort study followed people over the first year following HCT to document positive and negative outcomes. Methods People with hematologic cancers treated by HCT completed complementary self-report instruments at four milestones: (a) pre-transplant (N = 88); (b) engraftment (N = 80); (c) short-term post-discharge (N = 60); and (d) long-term post-discharge (N = 45). We examined symptoms, side effects, illness intrusiveness, depressive symptoms, positive and negative affect, and self- esteem. We compared QOL in HCT with diverse published values. Results QOL deteriorated following HCT. Most variables returned to baseline by short-term post-discharge, but self-esteem and illness intrusiveness required more time. Illness intrusiveness at 1 year post-discharge was higher in HCT than other cancer groups; negative affect, too, was higher, but HCT survivors also reported higher positive affect. HCT and other cancer survivors reported similar depressive symptom levels. Compared to healthy people, HCT survivors reported more severe depressive symptoms, but similar positive and negative affect. Conclusions QOL changes dramatically following HCT. People report more interference with valued activities and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Supportive Care in Cancer Springer Journals

Quality of life trajectories during the first year following hematopoietic cell transplantation: an inception cohort study

8 pages
Read Article

Loading next page...
 
/lp/springer_journal/quality-of-life-trajectories-during-the-first-year-following-M0XtFrLLYK
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Nursing; Nursing Research; Pain Medicine; Rehabilitation Medicine
ISSN
0941-4355
eISSN
1433-7339
D.O.I.
10.1007/s00520-018-4059-7
Publisher site
See Article on Publisher Site

Abstract

Background Allogeneic hematopoietic cell transplantation (HCT) affects quality of life (QOL). Patient-reported outcomes examine symptoms, side effects, distress, and physical and social problems, but positive outcomes have been ignored. This inception cohort study followed people over the first year following HCT to document positive and negative outcomes. Methods People with hematologic cancers treated by HCT completed complementary self-report instruments at four milestones: (a) pre-transplant (N = 88); (b) engraftment (N = 80); (c) short-term post-discharge (N = 60); and (d) long-term post-discharge (N = 45). We examined symptoms, side effects, illness intrusiveness, depressive symptoms, positive and negative affect, and self- esteem. We compared QOL in HCT with diverse published values. Results QOL deteriorated following HCT. Most variables returned to baseline by short-term post-discharge, but self-esteem and illness intrusiveness required more time. Illness intrusiveness at 1 year post-discharge was higher in HCT than other cancer groups; negative affect, too, was higher, but HCT survivors also reported higher positive affect. HCT and other cancer survivors reported similar depressive symptom levels. Compared to healthy people, HCT survivors reported more severe depressive symptoms, but similar positive and negative affect. Conclusions QOL changes dramatically following HCT. People report more interference with valued activities and

Journal

Supportive Care in Cancer – Springer Journals

Published: Feb 8, 2018

References

  • Stress among allogeneic bone marrow transplantation patients
    Heinonen, H; Volin, L; Zevon, MA; Uutela, A; Barrick, C; Ruutu, T
  • Quality of life concerns and depression among hematopoietic stem cell transplant survivors
    Mosher, CE; Duhamel, KN; Rini, C; Corner, G; Lam, J; Redd, WH
  • Patients’ perception of health-related quality of life during the first year after autologous and allogeneic stem cell transplantation
    Andersson, I; Ahlberg, K; Stockelberg, D; Persson, LO
  • Quality of life in patients before and after haematopoietic stem cell transplantation measured with the European Organization for Research and Treatatment of Cancer (EORTC) quality of life core questionnaire (QLQ-C30)
    Grulke, N; Albani, C; Bailer, H
  • A prospective evaluation of patients’ health-related quality of life during auto-SCT: a 3-year follow-up
    Frödin, U; Börjeson, S; Lyth, J; Lofti, K
  • Health-related quality of life in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation
    Bevans, MF; Marden, S; Leidy, NK; Soeken, K; Cusack, G; Rivera, P
  • Context moderates illness-induced lifestyle disruptions across life domains: a test of the illness intrusiveness theoretical framework in six common cancers
    Devins, GM; Bezjak, A; Mah, K; Loblaw, DA; Gotowiec, A
  • Illness intrusiveness in survivors of autologous bone and marrow transplantation
    Schimmer, AD; Elliott, ME; Abbey, SE; Raiz, L; Keating, A; Beanlands, HJ; McCay, E; Messner, HA; Lipton, JH; Devins, GM
  • The structure of psychological well-being
    Bradburn, NM
  • Are psychosocial factors associated with quality of life in patients with haematological cancer? A critical review of the literature
    Allart, P; Soubeyran, P; Cousson-Gélie, F
  • Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation
    Morishita, S; Kaida, K; Ikegame, K; Yoshihara, S; Taniguchi, K; Okada, M; Kodama, N; Ogawa, H; Domen, K
  • Returning to normal following bone marrow transplantation: outcomes, expectations and informed consent
    Andrykowski, MA; Brady, MJ; Greiner, CB; Altmaier, EM; Burish, TG; Antin, JH
  • The emotional impact of end-stage renal disease: importance of patients’ perceptions of intrusiveness and control
    Devins, GM; Binik, YM; Hutchinson, TA; Hollomby, DJ; Barre, PE; Guttmann, RD
  • Using the illness intrusiveness ratings scale to understand health-related quality of life in chronic disease
    Devins, GM
  • The structure of lifestyle disruptions in chronic disease: a confirmatory factor analysis of the illness intrusiveness ratings scale
    Devins, GM; Dion, R; Pelletier, LG; Shapiro, CM; Abbey, SE; Raiz, L
  • Psychometric theory
    Nunnally, JC
  • The CES-D scale: a self-report depression scale for research in the general population
    Radloff, LS
  • Screening for depression in head and neck cancer
    Katz, MR; Kopek, N; Waldron, J; Devins, GM; Tomlinson, G
  • Measuring depressive symptoms in illness populations: psychometric properties of the Center for Epidemiologic Studies Depression (CES-D) scale
    Devins, GM; Orme, CM; Costello, CG; Binik, YM; Frizzell, B; Stam, HJ
  • Society and the adolescent self-image
    Rosenberg, M
  • Measures of personality and social psychological attitudes
    Robinson, JP; Shaver, PR; Wrightsman, LS
  • The memorial symptom assessment scale: an instrument for the evaluation of symptom prevalence, characteristics and distress
    Portenoy, RK; Thaler, HT; Kornblith, AB; Lepore, JM; Friedlander-Klar, H; Kiyasu, E
  • Self-concept as a “BMT patient”, illness intrusiveness, and engulfment in allogeneic bone marrow transplant recipients
    Beanlands, HJ; Lipton, JH; McCay, EA; Schimmer, AD; Elliott, ME; Messner, HA; Devins, GM
  • Comparing personal trajectories and drawing causal inferences from longitudinal data
    Raudenbush, SW
  • Applied longitudinal data analysis: modeling change and event occurrence
    Singer, JD; Willett, JB
  • The experience of caregivers of hematological cancer patients undergoing a hematopoietic stem cell transplant: a comprehensive literature review
    Beattie, S; Lebel, S
  • Prevalence and incidence studies of mood disorders: a systematic review of the literature
    Waraich, P; Goldner, EM; Somers, JM; Hsu, L
  • Oral symptom intensity, health-related quality of life, and correlative salivary cytokines in adult survivors of hematopoietic stem cell transplantation with oral chronic graft-versus-host disease
    Fall-Dickson, JM; Mitchell, SA; Marden, S; Ramsay, ES; Guadagnini, J-P; Wu, T; St John, L; Pavletic, SZ
  • Distress and psychiatric morbidity among women from high-risk breast and ovarian cancer families
    Coyne, JC; Benazon, NR; Gaba, CG; Calzone, K; Weber, BL
  • The burden of stress in head and neck cancer
    Devins, GM; Payne, AYM; Lebel, S; Mah, K; Lee, RNF; Irish, JC
  • Head and neck cancer
    Devins, GM; Otto, KJ; Irish, JC; Rodin, GM

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial