Support Care Cancer (2018) 26:1233–1242 https://doi.org/10.1007/s00520-017-3946-7 ORIGINAL ARTICLE Quality of life of patients with locally advanced head and neck cancer treated with induction chemotherapy followed by cisplatin-containing chemoradiotherapy in the Dutch CONDOR study: a randomized controlled trial 1 2 3 Chantal M. L. Driessen & Johannes M. M. Groenewoud & Jan Paul de Boer & 4 1,5 6 Hans Gelderblom & Winette T. A. van der Graaf & Judith B. Prins & 7 1 Johannes H. A. M. Kaanders & Carla M. L. van Herpen Received: 17 February 2017 /Accepted: 23 October 2017 /Published online: 11 December 2017 The Author(s) 2017. This article is an open access publication Abstract 24 months after completion of chemoradiotherapy using the Purpose The CONDOR study showed that docetaxel/cisplat- EORTC-QLQ-C30 and QLQ-H&N35 in 62 patients. in/5-fluorouracil (TPF) followed by conventional radiothera- Results Compliance with the QOL questionnaires was 94% py with cisplatin 100 mg/m on days 1, 22, and 43 (cis100 + (59/62) at baseline and 61% (30/49) at 12 months, respective- RT; n = 27)) versus accelerated radiotherapy with cisplatin ly. HRQOL decreased after TPF and further decreased during weekly 40 mg/m (cis40 + ART; n = 29) in locally advanced chemoradiohteray in
Supportive Care in Cancer – Springer Journals
Published: Dec 11, 2017
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