Surg Today (2018) 48:101–109 https://doi.org/10.1007/s00595-017-1562-2 ORIGINAL ARTICLE Pulmonary endothelial chimerism after hematopoietic stem cell transplantation 1 1 2 Kyoko Hijiya · Toyofumi Fengshi Chen‑Yoshikawa · Aya Miyagawa‑Hayashino · 3 1 2 3 Tadakazu Kondo · Akihiro Aoyama · Hironori Haga · Akifumi Takaori‑Kondo · Hiroshi Date Received: 7 February 2017 / Accepted: 4 June 2017 / Published online: 8 July 2017 © Springer Japan KK 2017 Abstract Conclusions Our results demonstrate that circulating Purpose Few studies have investigated pulmonary stem cells engraft into the endothelium to a considerable endothelial chimerism after hematopoietic stem cell trans- extent in pulmonary chronic GVHD. plantation. In the present study, we investigated pulmonary endothelial chimerism using the ABH histo-blood group Keywords Chronic graft-versus-host disease · antigen as an identifying marker in cases of ABO-incom- Chimerism · Lung · Endothelium · Hematopoietic stem cell patible hematopoietic stem cell transplantation. transplantation · ABH histo-blood group antigen Methods Sixteen lung samples were analyzed. Of these, seven were explanted lungs from lung transplant recipients with severe pulmonary chronic graft-versus-host disease Introduction (GVHD). The remaining nine were autopsy samples from patients who died from various causes, and six of these After hematopoietic stem cell transplantation (HSCT), nine cases had a diagnosis of pulmonary chronic GVHD. circulating stem cells migrate to various tissues (i.e.,
Surgery Today – Springer Journals
Published: Jul 8, 2017
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