PTSA-catalyzed straightforward novel approach for the synthesis of 1,2-bis(4-nitrophenyl)-1H-benzo[f]chromen-3-amine and the evaluation of their antituberculosis activity

PTSA-catalyzed straightforward novel approach for the synthesis of... Keywords Multicomponent reaction  p-Toluenesulfonic acid  1H- benzo[f]chromen-3-amine derivatives  Mycobacterium tuberculosis strain Antituberculosis activity Introduction Tuberculosis (TB) is one of the oldest chronic granulomatous disease and the world’s 2nd most common serious infectious disease, which is out of control in many developing countries [1, 2]. It is an immanent and highly communicable bacterial disease; about 1/3rd of the world population are infected with the Mycobacterium tuberculosis H RV strain [3]. As per a report of the World Health Organization, 9 million people are infected with TB and about 1.7 million die annually, while in India every year nearly 2 million people suffer from TB and 0.5 million die [4]. Multidrug resistance (MDR), extensive drug resistance (XDR) and total drug resistance (TDR) cause major challenges for the control and fight against tuberculosis [5, 6]. Medicinal chemists have significant and challenging targets when searching for new entities for TB treatment [7]. A literature study has shown that there are several chromene analogues I and II which strongly demonstrate significant antituberculosis activity (Fig. 1)[8, 9]. The chromene (benzopyran) class is distinguished as one of the most important oxygen-containing heterocycles in cotemporary organic chemistry [10]. In modern drug discovery, these chromene http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

PTSA-catalyzed straightforward novel approach for the synthesis of 1,2-bis(4-nitrophenyl)-1H-benzo[f]chromen-3-amine and the evaluation of their antituberculosis activity

Loading next page...
 
/lp/springer_journal/ptsa-catalyzed-straightforward-novel-approach-for-the-synthesis-of-1-2-uOz4iERHge
Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2865-z
Publisher site
See Article on Publisher Site

Abstract

Keywords Multicomponent reaction  p-Toluenesulfonic acid  1H- benzo[f]chromen-3-amine derivatives  Mycobacterium tuberculosis strain Antituberculosis activity Introduction Tuberculosis (TB) is one of the oldest chronic granulomatous disease and the world’s 2nd most common serious infectious disease, which is out of control in many developing countries [1, 2]. It is an immanent and highly communicable bacterial disease; about 1/3rd of the world population are infected with the Mycobacterium tuberculosis H RV strain [3]. As per a report of the World Health Organization, 9 million people are infected with TB and about 1.7 million die annually, while in India every year nearly 2 million people suffer from TB and 0.5 million die [4]. Multidrug resistance (MDR), extensive drug resistance (XDR) and total drug resistance (TDR) cause major challenges for the control and fight against tuberculosis [5, 6]. Medicinal chemists have significant and challenging targets when searching for new entities for TB treatment [7]. A literature study has shown that there are several chromene analogues I and II which strongly demonstrate significant antituberculosis activity (Fig. 1)[8, 9]. The chromene (benzopyran) class is distinguished as one of the most important oxygen-containing heterocycles in cotemporary organic chemistry [10]. In modern drug discovery, these chromene

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jan 27, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off