PTSA-catalyzed straightforward novel approach for the synthesis of 1,2-bis(4-nitrophenyl)-1H-benzo[f]chromen-3-amine and the evaluation of their antituberculosis activity

PTSA-catalyzed straightforward novel approach for the synthesis of... Keywords Multicomponent reaction  p-Toluenesulfonic acid  1H- benzo[f]chromen-3-amine derivatives  Mycobacterium tuberculosis strain Antituberculosis activity Introduction Tuberculosis (TB) is one of the oldest chronic granulomatous disease and the world’s 2nd most common serious infectious disease, which is out of control in many developing countries [1, 2]. It is an immanent and highly communicable bacterial disease; about 1/3rd of the world population are infected with the Mycobacterium tuberculosis H RV strain [3]. As per a report of the World Health Organization, 9 million people are infected with TB and about 1.7 million die annually, while in India every year nearly 2 million people suffer from TB and 0.5 million die [4]. Multidrug resistance (MDR), extensive drug resistance (XDR) and total drug resistance (TDR) cause major challenges for the control and fight against tuberculosis [5, 6]. Medicinal chemists have significant and challenging targets when searching for new entities for TB treatment [7]. A literature study has shown that there are several chromene analogues I and II which strongly demonstrate significant antituberculosis activity (Fig. 1)[8, 9]. The chromene (benzopyran) class is distinguished as one of the most important oxygen-containing heterocycles in cotemporary organic chemistry [10]. In modern drug discovery, these chromene http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

PTSA-catalyzed straightforward novel approach for the synthesis of 1,2-bis(4-nitrophenyl)-1H-benzo[f]chromen-3-amine and the evaluation of their antituberculosis activity

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Publisher
Springer Netherlands
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2865-z
Publisher site
See Article on Publisher Site

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