An efficient p-toluenesulfonic acid catalyzed synthesis of 11H-benzo[a]benzo[6,7]chromeno[2,3-c]phenazine-11,16(17H)-dione derivatives has been described by one-pot, four-component condensation of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aromatic aldehydes using polyethylene glycol as solvent. This domino protocol produces biologically considerable heterocycles with the formation of C–C, C=C, C–N, C=N, C–O bonds in a single operation and this efficient green process provides significant advantages such as: operational simplicity, easy work-up procedure, high yields, avoidance of hazardous or toxic catalysts and organic solvents, and is devoid of inessential derivatization and generation of hazardous substances.
Research on Chemical Intermediates – Springer Journals
Published: Jan 14, 2016
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