Proton Pumping in the Secretory Pathway

Proton Pumping in the Secretory Pathway J. Membrane Biol. 182, 159–169 (2001) The Journal of DOI: 10.1007/s00232-001-0040-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review V.Th.G. Schoonderwoert and G.J.M. Martens Department of Animal Physiology, University of Nijmegen, Geert Grooteplein Zuid 28, 193RT, 6525 GA Nijmegen, The Netherlands Received: 9 November 2000/Revised: 11 January 2001 Introduction a device for active transport; it controls the transport of nutrients and waste products, and generates differences Protons are pumped into intracellular compartments in ion concentrations between the outside and inside of (e.g., lysosomes, endosomes, coated vesicles, synaptic the membrane-enclosed environment. Protons are vesicles and secretory granules) to create a proton motive pumped across a membrane by proton-ATPases that hy- force across the membrane or to acidify the lumen, which drolyze ATP, thereby generating a proton-motive force is necessary to perform cellular processes such as hydro- (pmf). Alternatively, the ATPases may utilize the en- lysis of macromolecules, receptor-mediated endocytosis ergy of the pmf for ATP formation [84]. Proton- and processing of preproproteins. The proton gradient is ATPases have been divided into three main classes, established and maintained by the H -pumping vacuolar- namely P-, F- and V-ATPases [101]. The P-type H - type ATPase (V-ATPase). Here we discuss http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Proton Pumping in the Secretory Pathway

Loading next page...
 
/lp/springer_journal/proton-pumping-in-the-secretory-pathway-MbGJC7ncoN
Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 2001 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-001-0040-2
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial