Proton Pumping in the Secretory Pathway

Proton Pumping in the Secretory Pathway J. Membrane Biol. 182, 159–169 (2001) The Journal of DOI: 10.1007/s00232-001-0040-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review V.Th.G. Schoonderwoert and G.J.M. Martens Department of Animal Physiology, University of Nijmegen, Geert Grooteplein Zuid 28, 193RT, 6525 GA Nijmegen, The Netherlands Received: 9 November 2000/Revised: 11 January 2001 Introduction a device for active transport; it controls the transport of nutrients and waste products, and generates differences Protons are pumped into intracellular compartments in ion concentrations between the outside and inside of (e.g., lysosomes, endosomes, coated vesicles, synaptic the membrane-enclosed environment. Protons are vesicles and secretory granules) to create a proton motive pumped across a membrane by proton-ATPases that hy- force across the membrane or to acidify the lumen, which drolyze ATP, thereby generating a proton-motive force is necessary to perform cellular processes such as hydro- (pmf). Alternatively, the ATPases may utilize the en- lysis of macromolecules, receptor-mediated endocytosis ergy of the pmf for ATP formation [84]. Proton- and processing of preproproteins. The proton gradient is ATPases have been divided into three main classes, established and maintained by the H -pumping vacuolar- namely P-, F- and V-ATPases [101]. The P-type H - type ATPase (V-ATPase). Here we discuss http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Proton Pumping in the Secretory Pathway

Loading next page...
 
/lp/springer_journal/proton-pumping-in-the-secretory-pathway-MbGJC7ncoN
Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 2001 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-001-0040-2
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 182, 159–169 (2001) The Journal of DOI: 10.1007/s00232-001-0040-2 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review V.Th.G. Schoonderwoert and G.J.M. Martens Department of Animal Physiology, University of Nijmegen, Geert Grooteplein Zuid 28, 193RT, 6525 GA Nijmegen, The Netherlands Received: 9 November 2000/Revised: 11 January 2001 Introduction a device for active transport; it controls the transport of nutrients and waste products, and generates differences Protons are pumped into intracellular compartments in ion concentrations between the outside and inside of (e.g., lysosomes, endosomes, coated vesicles, synaptic the membrane-enclosed environment. Protons are vesicles and secretory granules) to create a proton motive pumped across a membrane by proton-ATPases that hy- force across the membrane or to acidify the lumen, which drolyze ATP, thereby generating a proton-motive force is necessary to perform cellular processes such as hydro- (pmf). Alternatively, the ATPases may utilize the en- lysis of macromolecules, receptor-mediated endocytosis ergy of the pmf for ATP formation [84]. Proton- and processing of preproproteins. The proton gradient is ATPases have been divided into three main classes, established and maintained by the H -pumping vacuolar- namely P-, F- and V-ATPases [101]. The P-type H - type ATPase (V-ATPase). Here we discuss

Journal

The Journal of Membrane BiologySpringer Journals

Published: Aug 1, 2001

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off