Protein/Protein Interactions (PDZ) in Proximal Tubules

Protein/Protein Interactions (PDZ) in Proximal Tubules J. Membrane Biol. 203, 111–118 (2005) DOI:10.1007/s00232-005-0738-7 Topical Review J. Biber, S.M. Gisler, N. Hernando, H. Murer Institute of Physiology, University of Zurich, 8057 Zu ¨ rich, Switzerland Received:30 September 2004/Revised: 10 February 2005 Introduction The PDZ module Essentially all cellular functions rely on the correct Numerous protein domains have been described that spatial organization of proteins. In epithelial cells, are implicated in protein-protein interactions (see e.g., this is manifested by a separation of the plasma Based on sequence similarities be- membrane into an apical and a basolateral area, tween the post-synaptic density protein PSD-95, the which is required for vectorial transport of solutes, Drosophila junctional protein Disc-large and the tight and by the formation of junctional complexes to junctional protein ZO1, one such domain was defined guarantee barrier function. In this article, we sum- as PDZ. PDZ proteins, among other functions, are marize the current knowledge of PDZ protein-based primarily thought to organize large functional units multimeric protein complexes in renal proximal such as synapses [55] or tight junctions [19]. The tubular (PT) cells (for definition of the PDZ domain, characteristics of PDZ domains have been reviewed see below), which are involved in the organization of recently The Journal of Membrane Biology Springer Journals

Protein/Protein Interactions (PDZ) in Proximal Tubules

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Copyright © 2005 by Springer Science+Business Media Inc.
Life Sciences; Human Physiology; Biochemistry, general
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