Protein prenylation in plants: old friends and new targets

Protein prenylation in plants: old friends and new targets Plant Molecular Biology 39: 865–870, 1999. © 1999 Kluwer Academic Publishers. Printed in the Netherlands. Mini-review ´ ´ Manuel Rodrıguez-Concepcion, Shaul Yalovsky and Wilhelm Gruissem Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkely, CA 94720, USA ( author for correspondence) Received 6 November 1998; accepted in revised form 19 November 1998 Introduction Proteins are modified by three types of prenyltransferases Protein prenylation is a post-translational protein Three different prenyltransferases catalyze protein modification that involves the formation of covalent prenylation reactions: a single farnesyl transferase thioether bonds between cysteines near the C-termini (FTase) and two geranylgeranyl transferases (GGTase- of target proteins and isoprenoid pathway interme- I and -II). Genetic analysis in yeast and biochemical diates 15-carbon farnesyldiphosphate (FPP) or 20- carbon geranylgeranyldiphosphate (GGPP). Protein studies in animals revealed that FTase and GGTase- prenylation was first discovered two decades ago as I are heterodimeric enzymes which share a com- a lipid modification of mating factors in fungi [10]. mon subunit but have distinc subunits that de- Later reports that all Ras proteins are prenylated [8] termine substrate specificity [21, 29]. Both FTase attracted much interest to protein prenylation in both and GGTase-I require zinc for catalytic Plant Molecular Biology Springer Journals

Protein prenylation in plants: old friends and new targets

Loading next page...
Kluwer Academic Publishers
Copyright © 1999 by Kluwer Academic Publishers
Life Sciences; Biochemistry, general; Plant Sciences; Plant Pathology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial