Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread

Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for... Mutational analysis of the phosphate acceptor sites of the Borna disease virus (BDV) phosphoprotein (P) has suggested a role of phosphorylation for viral spread. However, the studied mutant viruses also had two amino acid exchanges in the X protein, because the reading frames of P and X overlap. To determine the relative contribution of P and X to viral attenuation, we studied a P variant with serine-to-leucine substitutions (P S26L,S28L ) in which the wild-type X sequence was conserved. Viral spread of rBDV-P S26L,S28L was impaired in human oligodendroglioma cells and in adult rats. Thus, BDV-P phosphorylation contributes to efficient viral dissemination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread

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Publisher
Springer Vienna
Copyright
Copyright © 2010 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-010-0645-9
Publisher site
See Article on Publisher Site

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