Protective Action of Xymedon on the Morphological Structures of the Pancreas of the Rat in Ischemia

Protective Action of Xymedon on the Morphological Structures of the Pancreas of the Rat in Ischemia Pathologic processes associated with the effect of ischemia on the pancreas are not yet fully investigated and searching for ways of reduction of the damaging effect of ischemia for providing full organ regeneration are of certain interest. Protective properties of xymedone with regard to pathologic processes in pancreas were studied on a model of total ischemia created by ligation of the coeliac and cranial mesenteric artery for 0 to 90 min. Pathologic structural changes in the pancreas in case of ischemia lasting up to 30 min are minor and therefore fully reversible. On the contrary, ischemia duration of more than 60 min in the group of animals not injected with xymedone can be seen as critical. We conclude that prior intraperitoneal injection of xymedone in the dose of 3.3 mg/kg helps to delay the development of pathologic processes in pancreatic parenchyma by approximately 30 min. . . . Keywords Ischemia Pancreas Pyrimidine derivative Xymedone 1 Introduction unstable. They can cause cell damage, primarily due to lipid peroxidation in cellular membranes and mitochondria, as well The issue of ischemic damages to various organs and tissues as DNA degradation [5]. It has been proven that overproduc- remains one of the most http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioNanoScience Springer Journals

Protective Action of Xymedon on the Morphological Structures of the Pancreas of the Rat in Ischemia

Loading next page...
 
/lp/springer_journal/protective-action-of-xymedon-on-the-morphological-structures-of-the-Z6sRsDPsOE
Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Engineering; Circuits and Systems; Biological and Medical Physics, Biophysics; Nanotechnology; Biomaterials
ISSN
2191-1630
eISSN
2191-1649
D.O.I.
10.1007/s12668-018-0530-7
Publisher site
See Article on Publisher Site

Abstract

Pathologic processes associated with the effect of ischemia on the pancreas are not yet fully investigated and searching for ways of reduction of the damaging effect of ischemia for providing full organ regeneration are of certain interest. Protective properties of xymedone with regard to pathologic processes in pancreas were studied on a model of total ischemia created by ligation of the coeliac and cranial mesenteric artery for 0 to 90 min. Pathologic structural changes in the pancreas in case of ischemia lasting up to 30 min are minor and therefore fully reversible. On the contrary, ischemia duration of more than 60 min in the group of animals not injected with xymedone can be seen as critical. We conclude that prior intraperitoneal injection of xymedone in the dose of 3.3 mg/kg helps to delay the development of pathologic processes in pancreatic parenchyma by approximately 30 min. . . . Keywords Ischemia Pancreas Pyrimidine derivative Xymedone 1 Introduction unstable. They can cause cell damage, primarily due to lipid peroxidation in cellular membranes and mitochondria, as well The issue of ischemic damages to various organs and tissues as DNA degradation [5]. It has been proven that overproduc- remains one of the most

Journal

BioNanoScienceSpringer Journals

Published: May 30, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off