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G. Zasukhina (2005)
Mechanisms of human cell protection associated with genetic polymorphismRussian Journal of Genetics, 41
(2008)
Protective Action of Antimutagens in Human RepairDefective Cells , Radiobiol
G. Zasukhina, I. Vasil’eva, A. Vedernikov, S. Gromov, M. Alfimov (2006)
Antimutagenic characteristics of new diazacrown compounds with N-carboxyalkyl substitutesBulletin of Experimental Biology and Medicine, 141
A. Durnev (2001)
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Ya.V. Malyutina, A.Ya. Kabakov (2007)
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Richard Brennan, Robert Schiestl (1996)
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I. Pelevina, A. Aleshchenko, M. Antoshchina, N. Riabchenko, L. Semenova, A. Serebrianyĭ (2007)
[An individual variability of the adaptive response to irradiation in human cells. Approach to its determination].Radiatsionnaia biologiia, radioecologiia, 47 6
E. Khandogina, G. Mutovin, S. Zvereva, D. Zverev, E. Neudakhin, B. Arkhipov, A. Akif'ev (1991)
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Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndromeBulletin of Experimental Biology and Medicine, 144
G.D. Zasukhina, A.D. Durnev, I.M. Vasilyeva (2003)
Antimutagenic and Antioxidant Activities of Crown Compounds in Comparison with the Effects of Garlic ExtractsByull. Eksp. Biol. Med., 135
N.S. Kuz’mina, E.V. Shipaeva, G.D. Zasukhina (2007)
Polymorphism of Detoxification Genes and Cell Resistance to Mutagens in Patients with Ehlers-Danlos SyndromeByull. Eksp. Biol. Med., 44
Maliutina IaV, K. Ae (2007)
Preirradiation heat shock protein induction increases cellular radioresistanceRadiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk, 47
G. Zasukhina, I. Vasil’eva, E. Mikhal'chik, A. Durnev, S. Gromov, O. Fedorova, M. Alfimov (2003)
Antimutagenic and Antioxidant Activities of Crown Compounds in Comparison with the Effects of Garlic ExtractBulletin of Experimental Biology and Medicine, 135
I.I. Pelevina, A.V. Aleshchenko, M.M. Antoshchina (2007)
Individual Variability of the Adaptive Response to Irradiation in Human CellsRadiobiol. Radioekol., 47
(2006)
Antimutagenic Characteristics of Diazacrown Compounds with NCarboxyalkyl Substitutes , Byull
U. Laemmli (1970)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophag T4Nature, 227
Konstantin Khetchoumian, Marius Teletin, J. Tisserand, M. Mark, B. Herquel, M. Ignat, J. Zucman‐Rossi, F. Cammas, T. Lerouge, C. Thibault, D. Metzger, P. Chambon, R. Losson (2007)
Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor alphaNature Genetics, 39
I.M. Vasilyeva, A.N. Semyachkina, G.D. Zasukhina (2008)
Protective Action of Antimutagens in Human Repair-Defective CellsRadiobiol. Radioekol., 48
Cells of a diploid line obtained from embryos with the Down’s syndrome, known to be unable to repair gamma-induced DNA damage, were treated with natural (garlic extract, retinol) and synthetic (crown compound) antimutagens and with adapting factors (heat shock, low CdCl2 concentrations, 10−8 M). The protective effect was evaluated by registering DNA breaks and cell survival, and the protection coefficients were calculated. The most effective results were obtained with the use of the garlic extract and retinol. No protection of the DNA structure was observed when cells were treated with low concentrations of cadmium chloride and then with high concentrations, i. e., no adaptive response (AR) was formed under these conditions. The spectrum of proteins in treated and control cells as well as detoxication genes (GSTM1, GSTT1, CYP1A1) were determined.
Russian Journal of Genetics – Springer Journals
Published: Jun 19, 2009
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