Prosthetic Joint Infections: an Update

Prosthetic Joint Infections: an Update Purpose of Review Prosthetic joint infection (PJI) is a rare but serious complication that is frequently misdiagnosed. We aimed to highlight the nuances of PJI diagnosis and antimicrobial therapies and provide clarity in key areas of management. Recent Findings Current research in PJI centers on a potential role for diagnostic biomarkers, molecular techniques, and implant sonication to reduce culture-negativity rates. The optimal duration of antimicrobial therapy remains controversial. Summary A high clinical index of suspicion for PJI combined with data from multiple preoperative and intraoperative tests enables timely diagnosis and treatment. Biomarkers, molecular methods, and implant sonication are currently adjunctive to traditional diagnostic techniques. Shorter courses of antimicrobial therapies as well as the role of chronic suppressive therapy need confirmation by randomized controlled trials. Existing practices for preoperative dental prophylaxis and treatment of asymptomatic bacteriuria warrant revision based on evidence arguing against risk for PJI. . . . . Keywords Prosthetic joint infection Diagnosis Management Controversies Suppressive antibiotic therapy Introduction PJI, also known as periprosthetic infection, is defined as infection involving the joint prosthesis and adjacent tissue. It Joint replacement surgery is a life-enhancing procedure for mil- is perhaps the most challenging complication associated with lions of people each http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Infectious Disease Reports Springer Journals

Prosthetic Joint Infections: an Update

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Infectious Diseases
ISSN
1523-3847
eISSN
1534-3146
D.O.I.
10.1007/s11908-018-0622-0
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review Prosthetic joint infection (PJI) is a rare but serious complication that is frequently misdiagnosed. We aimed to highlight the nuances of PJI diagnosis and antimicrobial therapies and provide clarity in key areas of management. Recent Findings Current research in PJI centers on a potential role for diagnostic biomarkers, molecular techniques, and implant sonication to reduce culture-negativity rates. The optimal duration of antimicrobial therapy remains controversial. Summary A high clinical index of suspicion for PJI combined with data from multiple preoperative and intraoperative tests enables timely diagnosis and treatment. Biomarkers, molecular methods, and implant sonication are currently adjunctive to traditional diagnostic techniques. Shorter courses of antimicrobial therapies as well as the role of chronic suppressive therapy need confirmation by randomized controlled trials. Existing practices for preoperative dental prophylaxis and treatment of asymptomatic bacteriuria warrant revision based on evidence arguing against risk for PJI. . . . . Keywords Prosthetic joint infection Diagnosis Management Controversies Suppressive antibiotic therapy Introduction PJI, also known as periprosthetic infection, is defined as infection involving the joint prosthesis and adjacent tissue. It Joint replacement surgery is a life-enhancing procedure for mil- is perhaps the most challenging complication associated with lions of people each

Journal

Current Infectious Disease ReportsSpringer Journals

Published: May 22, 2018

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