Prospects for complex trait analysis in the mouse

Prospects for complex trait analysis in the mouse Mamm Genome (2008) 19:306–308 DOI 10.1007/s00335-008-9110-4 COMMEN T ARY S ER IE S: F U TUR E CH ALLENG E S AND OP POR T UNITIES IN M A MM A L IAN F UNC TIONAL GENO M I CS Richard Mott Æ Jonathan Flint Received: 1 April 2008 / Accepted: 25 April 2008 / Published online: 21 May 2008 The Author(s) 2008 We want to discuss how recent dramatic progress in whole- of kilobases, usually the span a single gene. Assuming that genome association analysis (WGA) applied to human case- the functional genetic variant acts on the nearest gene control studies will affect complex trait analysis in the (which is not always the case), then human WGA delivers mouse. At first sight it might now seem that one can identify single-gene resolution. In contrast, a detected QTL in an F the genetic determinants of human complex disease intercross between two inbred laboratory mouse strains that directly. However, the picture is less straightforward, for explains 5% of the phenotypic variance will be mapped although a significant number of genes have been identified into a 95% confidence interval of approximately 30 Mb, and replicated across different human WGA studies, in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Prospects for complex trait analysis in the mouse

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Publisher
Springer-Verlag
Copyright
Copyright © 2008 by The Author(s)
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-008-9110-4
Publisher site
See Article on Publisher Site

Abstract

Mamm Genome (2008) 19:306–308 DOI 10.1007/s00335-008-9110-4 COMMEN T ARY S ER IE S: F U TUR E CH ALLENG E S AND OP POR T UNITIES IN M A MM A L IAN F UNC TIONAL GENO M I CS Richard Mott Æ Jonathan Flint Received: 1 April 2008 / Accepted: 25 April 2008 / Published online: 21 May 2008 The Author(s) 2008 We want to discuss how recent dramatic progress in whole- of kilobases, usually the span a single gene. Assuming that genome association analysis (WGA) applied to human case- the functional genetic variant acts on the nearest gene control studies will affect complex trait analysis in the (which is not always the case), then human WGA delivers mouse. At first sight it might now seem that one can identify single-gene resolution. In contrast, a detected QTL in an F the genetic determinants of human complex disease intercross between two inbred laboratory mouse strains that directly. However, the picture is less straightforward, for explains 5% of the phenotypic variance will be mapped although a significant number of genes have been identified into a 95% confidence interval of approximately 30 Mb, and replicated across different human WGA studies, in

Journal

Mammalian GenomeSpringer Journals

Published: May 21, 2008

References

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