Mamm Genome (2008) 19:306–308 DOI 10.1007/s00335-008-9110-4 COMMEN T ARY S ER IE S: F U TUR E CH ALLENG E S AND OP POR T UNITIES IN M A MM A L IAN F UNC TIONAL GENO M I CS Richard Mott Æ Jonathan Flint Received: 1 April 2008 / Accepted: 25 April 2008 / Published online: 21 May 2008 The Author(s) 2008 We want to discuss how recent dramatic progress in whole- of kilobases, usually the span a single gene. Assuming that genome association analysis (WGA) applied to human case- the functional genetic variant acts on the nearest gene control studies will affect complex trait analysis in the (which is not always the case), then human WGA delivers mouse. At ﬁrst sight it might now seem that one can identify single-gene resolution. In contrast, a detected QTL in an F the genetic determinants of human complex disease intercross between two inbred laboratory mouse strains that directly. However, the picture is less straightforward, for explains 5% of the phenotypic variance will be mapped although a signiﬁcant number of genes have been identiﬁed into a 95% conﬁdence interval of approximately 30 Mb, and replicated across different human WGA studies, in
Mammalian Genome – Springer Journals
Published: May 21, 2008
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