Cardiovasc Intervent Radiol (2017) 40:1196–1205 DOI 10.1007/s00270-017-1630-4 CLINICAL INVESTIGATION INTERVENTIONAL ONCOLOGY Prospective Clinical and Pharmacological Evaluation of the Delcath System’s Second-Generation (GEN2) Hemoﬁltration System in Patients Undergoing Percutaneous Hepatic Perfusion with Melphalan 1 2 2 • • • Eleonora M. de Leede Mark C. Burgmans T. Susanna Meijer 3 4 3 2 • • • • Christian H. Martini Fred G. J. Tijl Jaap Vuyk Arian R. van Erkel 1 5 1 • • Cornelis J. H. van der Velde Ellen Kapiteijn Alexander L. Vahrmeijer Received: 7 December 2016 / Accepted: 15 March 2017 / Published online: 27 April 2017 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017 Abstract determine ﬁlter efﬁciency and systemic drug exposure. Introduction Percutaneous hepatic perfusion (PHP) with PHP was performed with melphalan 3 mg/kg with a melphalan is an effective treatment for patients with hep- maximum of 220 mg. Complications were assessed atic metastases, but associated with high rates of bone according to CTCAE v4.03. Response was assessed marrow depression. To reduce systemic toxicity, according to RECIST 1.1. improvements have been made to the ﬁltration system. In Results Pharmacokinetic analysis of blood samples pre-clinical studies, the
CardioVascular and Interventional Radiology – Springer Journals
Published: Apr 27, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera