Propylthiouracil/thiamazole

Propylthiouracil/thiamazole Reactions 1680, p289 - 2 Dec 2017 Extensive erythroderma and agranulocytosis: case report A 25-year-old woman developed repeated episodes of extensive erythroderma during treatment with thiamazole [methimazole] and agranulocytosis during treatment with propylthiouracil [routes and times to reactions onset not stated; not all dosages and outcomes stated]. In 2007, the woman was diagnosed with Grave’s disease hyperthyroidism. Later, she was started on treatment with thiamazole. She developed repeated episodes of extensive erythroderma, which was considered to be thiamazole allergy. Therefore, thiamazole was discontinued. Subsequently, the woman was started on propylthiouracil 300 mg/day for 11 months. Eventually, she was admitted for the investigation of agranulocytosis. She was found to be tachycardic and febrile on physical examination.She was started on piperacillin/ tazobactam and unspecified steroid for 16 days, while fever persisted for 11 days. Laboratory tests showed low platelet count and low leukocyte count with granulocyte count of only 2%. Laboratory tests also showed LDH of 826 IU/L, mean cell volume (MCV) of 90fL, haptoglobin of <10 mg/dL, total bilirubin of 2.70 mg/dL, direct bilirubin of 0.64 mg/dL, CRP of 37 mg/L and ESR 40 mm/h. Bone marrow aspirate and biopsy revealed a normocellular haematopoietic parenchyma with clear selective decline of granulopoiesis with no lymphoid or blastic cells infiltrates. Ultrasound abdomen showed a slight growth in spleen size. Based on these findings, a diagnosis of propylthiouracil-induced agranulocytosis was made, which was complicated by uroseptic fever and thyro-gastric syndrome. The treatment with propylthiouracil was discontinued and she was started on propranolol. She also received treatment with 8 doses of granulocyte colony- stimulating factor (G-CSF). Later, she underwent thyroidectomy. Two year post-thyroidectomy, she was doing well and had a normal granulocyte count. Author comment: "Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients)." "Here we report a rare case of a patient with hyperthyroidism and Graves’ disease, allergic to methimazole, treated with propylthiouracil, who developed a propylthiouracil-related agranulocytosis." Candoni A, et al. Graves&apos; disease thyrotoxicosis and propylthiouracil related agranulocytosis successfully treated with therapeutic plasma exchange and G-CSF followed by total thyroidectomy. Mediterranean Journal of Hematology and Infectious Diseases 9: No. 1, Oct 2017. Available from: URL: http:// doi.org/10.4084/mjhid.2017.058 - Italy 803284611 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Propylthiouracil/thiamazole

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
Free
1 page

Loading next page...
1 Page
 
/lp/springer_journal/propylthiouracil-thiamazole-1hi04QWASe
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39220-5
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial