Properties and the Cytoskeletal Control of Ca++-independent Large Conductance K+ Channels in Neonatal Rat Hippocampal Neurons

Properties and the Cytoskeletal Control of Ca++-independent Large Conductance K+ Channels in... A member of the family of Ca++-independent large conductance K+ channels (termed BK channels) was identified in patch clamp experiments with cultured neonatal rat hippocampal neurons. Permeation was characterized (at 5 mmol/l external, 140 mmol/l internal K+; 135 mmol/l external Na+) by a conductance of 107 pS, a ratio PNa/PK∼ 0.01, and outward rectification near the reversal potential. Channel activity was not voltage-dependent, could not be reduced by internal TEA or by a shift of internal pH from 7.4 to 6.8, i.e., discriminating features within the Ca++-independent BK channel family. Cytosolic proteolysis abolished the functional state of hippocampal Ca++-independent BK channels, in contrast to the pronase resistance of hippocampal Ca++-activated BK channels which suggests structural dissimilarities between these related channels. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Properties and the Cytoskeletal Control of Ca++-independent Large Conductance K+ Channels in Neonatal Rat Hippocampal Neurons

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1998 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900334
Publisher site
See Article on Publisher Site

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