Propafenone overdose

Propafenone overdose Reactions 1680, p287 - 2 Dec 2017 O S Various toxicities following suicide attempt: case report A 36-year-old woman developed loss of consiousness, generalised tonic-clonic seizure, decreased blood pressure, Brugada ECG pattern, cardiac arrest and acquired sodium channel dysfunction, following suicide attempt with propafenone overdose [durations of treatment to reaction onsets not stated]. The woman was admitted to the emergency room due to suicidal attempt using 36 tablets of propafenone 150mg. Subsequently, she developed generalised tonic-clonic seizure and loss of consciousness. A physical examination showed BP of 70/40mm Hg and a HR of 95 bpm. An initial 12 lead ECG showed irregular wide QRS rhythm with a QRS duration of 160msec and ST-segment elevation in leads V –V . These 1 2 findings corresponded to a Brugada ECG pattern. Subsequently, she developed cardiac arrest. The woman underwent cardiopulmonary resuscitation with restoration of electrical activity. A day after, the 12 lead ECG revealed resolution of the Brugada ECG pattern. An ajmaline challenge test failed to develop a Brugada ECG pattern. She was discharged with follow-up activity. It was known that a large dose of propafenone may turn the sodium channel dysfunctional, and thus she developed acquired sodium channel dysfunction. Author comment: "We present a case of a suicidal attempt using a high dose of propafenone causing a Brugada- type electrocardiographic pattern." "[T]his case could labeled as "acquired sodium channel dysfunction," induced by a toxic dose of propafenone". Kocabas U, et al. Brugada syndrome, Brugada phenocopy or none?. Annals of Noninvasive Electrocardiology 22: e12470, No. 6, Nov 2017. Available from: URL: http://doi.org/10.1111/anec.12470 - Turkey 803284974 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Propafenone overdose

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39218-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p287 - 2 Dec 2017 O S Various toxicities following suicide attempt: case report A 36-year-old woman developed loss of consiousness, generalised tonic-clonic seizure, decreased blood pressure, Brugada ECG pattern, cardiac arrest and acquired sodium channel dysfunction, following suicide attempt with propafenone overdose [durations of treatment to reaction onsets not stated]. The woman was admitted to the emergency room due to suicidal attempt using 36 tablets of propafenone 150mg. Subsequently, she developed generalised tonic-clonic seizure and loss of consciousness. A physical examination showed BP of 70/40mm Hg and a HR of 95 bpm. An initial 12 lead ECG showed irregular wide QRS rhythm with a QRS duration of 160msec and ST-segment elevation in leads V –V . These 1 2 findings corresponded to a Brugada ECG pattern. Subsequently, she developed cardiac arrest. The woman underwent cardiopulmonary resuscitation with restoration of electrical activity. A day after, the 12 lead ECG revealed resolution of the Brugada ECG pattern. An ajmaline challenge test failed to develop a Brugada ECG pattern. She was discharged with follow-up activity. It was known that a large dose of propafenone may turn the sodium channel dysfunctional, and thus she developed acquired sodium channel dysfunction. Author comment: "We present a case of a suicidal attempt using a high dose of propafenone causing a Brugada- type electrocardiographic pattern." "[T]his case could labeled as "acquired sodium channel dysfunction," induced by a toxic dose of propafenone". Kocabas U, et al. Brugada syndrome, Brugada phenocopy or none?. Annals of Noninvasive Electrocardiology 22: e12470, No. 6, Nov 2017. Available from: URL: http://doi.org/10.1111/anec.12470 - Turkey 803284974 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

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