Propafenone overdose

Propafenone overdose Reactions 1680, p287 - 2 Dec 2017 O S Various toxicities following suicide attempt: case report A 36-year-old woman developed loss of consiousness, generalised tonic-clonic seizure, decreased blood pressure, Brugada ECG pattern, cardiac arrest and acquired sodium channel dysfunction, following suicide attempt with propafenone overdose [durations of treatment to reaction onsets not stated]. The woman was admitted to the emergency room due to suicidal attempt using 36 tablets of propafenone 150mg. Subsequently, she developed generalised tonic-clonic seizure and loss of consciousness. A physical examination showed BP of 70/40mm Hg and a HR of 95 bpm. An initial 12 lead ECG showed irregular wide QRS rhythm with a QRS duration of 160msec and ST-segment elevation in leads V –V . These 1 2 findings corresponded to a Brugada ECG pattern. Subsequently, she developed cardiac arrest. The woman underwent cardiopulmonary resuscitation with restoration of electrical activity. A day after, the 12 lead ECG revealed resolution of the Brugada ECG pattern. An ajmaline challenge test failed to develop a Brugada ECG pattern. She was discharged with follow-up activity. It was known that a large dose of propafenone may turn the sodium channel dysfunctional, and thus she developed acquired sodium channel dysfunction. Author comment: "We present a case of a suicidal attempt using a high dose of propafenone causing a Brugada- type electrocardiographic pattern." "[T]his case could labeled as "acquired sodium channel dysfunction," induced by a toxic dose of propafenone". Kocabas U, et al. Brugada syndrome, Brugada phenocopy or none?. Annals of Noninvasive Electrocardiology 22: e12470, No. 6, Nov 2017. Available from: URL: - Turkey 803284974 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Propafenone overdose

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial