Adv Ther (2017) 34:2601–2611 DOI 10.1007/s12325-017-0640-6 ORIGINAL RESEARCH Prolonging Time to Flare in Pediatric Atopic Dermatitis: A Randomized, Investigator-Blinded, Controlled, Multicenter Clinical Study of a Ceramide- Containing Moisturizer . . . . . Lin Ma Ping Li Jianping Tang Yifeng Guo Chunping Shen Jing Chang Nabil Kerrouche Received: September 9, 2017 / Published online: November 16, 2017 Springer Healthcare Ltd., part of Springer Nature 2017 were randomized to receive moisturizer twice ABSTRACT daily and body wash once daily, or body wash alone once daily for 12 weeks. The primary Introduction: Delaying or preventing ﬂares is efﬁcacy endpoint was time to ﬂare [necessitat- important in atopic dermatitis (AD) manage- ing medical therapy and/or Investigator Global ment. The objective of the study was to evaluate Assessment (IGA)[1 (at least mild AD)]. Other whether using a ceramide-containing moistur- efﬁcacy endpoints were AD characteristics and izer in addition to a body wash during latent AD emollient effects. The patient-reported outcome can delay ﬂares. comprised satisfaction at week 12. The safety Methods: This was a randomized, investiga- endpoint was incidence of undesirable events. tor-blinded, parallel-group, controlled study Results: A total of 64 subjects aged 2–12 years among Chinese children with a history of mild
Advances in Therapy – Springer Journals
Published: Nov 16, 2017
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