Breast Cancer Res Treat (2017) 165:329–341 DOI 10.1007/s10549-017-4304-7 CLINICAL TRIAL Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial 1 2 3 4 • • • • Javier Corte ´s Hope S. Rugo Ahmad Awada Chris Twelves 5 6 7 8 • • • • Edith A. Perez Seock–Ah Im Patricia Go ´ mez-Pardo Lee S. Schwartzberg 9 10 11 12 ´ • • • • Veronique Dieras Denise A. Yardley David A. Potter Audrey Mailliez 1 13 14 14 • • • • Alvaro Moreno-Aspitia Jin-Seok Ahn Carol Zhao Ute Hoch 14 15 16 • • Mary Tagliaferri Alison L. Hannah Joyce O’Shaughnessy Received: 12 May 2017 / Accepted: 16 May 2017 / Published online: 13 June 2017 The Author(s) 2017. This article is an open access publication Abstract those with treated, stable brain metastases. The primary Purpose Conventional chemotherapy has limited activity endpoint, overall survival (OS), was assessed in a pre-de- in patients with breast cancer and brain metastases ﬁned subgroup of BCBM patients; an exploratory post hoc (BCBM). Etirinotecan pegol (EP), a novel long-acting analysis adjusting for the diagnosis-speciﬁc
Breast Cancer Research and Treatment – Springer Journals
Published: Jun 13, 2017
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