Prolongation of MGE 412 Transposition Induction after γ-Irradiation in an Isogenic Line of Drosophila melanogaster

Prolongation of MGE 412 Transposition Induction after γ-Irradiation in an Isogenic Line of... The dose dependence of the rate of γ-induced transpositions and consequent dynamics of the MGE 412pattern after γ-irradiation were investigated in isogenic line 49 in generations F1, F12, F140, and F170. It was shown that the results on dose dependence of transpositions was very similar with the corresponding results of the classic works by Timofeeff-Ressovsky et al.(1935). It is suggested that the transcribed copies of retrotransposon 412“cure” γ-radiation-induced double-strand DNA breaks. The phenomenon of prolongation of MGE transposition induction during early generations after treatment was shown. In this period (F1–F12), the maximum transposition rate (λ ≃ 2 × 10–2events per MGE copy, per haploid genome, per generation) and the maximum number of heterozygous MGE copies were achieved. In the late generations (F140–F170), the reduced induction level (λ ∼ 10–3) was established. In the population of effective size N e= 2000 individuals, this corresponds to the state when λ ≫ 1/4N e, i.e., when the transposition flow prevails over the MGE copy loss by genetic drift. These data together with some indirect evidence argue for the hypothesis that the spontaneous transposition rate is proportional to the average number of heterozygous MGE copies per diploid genome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Prolongation of MGE 412 Transposition Induction after γ-Irradiation in an Isogenic Line of Drosophila melanogaster

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1016698225212
Publisher site
See Article on Publisher Site

Abstract

The dose dependence of the rate of γ-induced transpositions and consequent dynamics of the MGE 412pattern after γ-irradiation were investigated in isogenic line 49 in generations F1, F12, F140, and F170. It was shown that the results on dose dependence of transpositions was very similar with the corresponding results of the classic works by Timofeeff-Ressovsky et al.(1935). It is suggested that the transcribed copies of retrotransposon 412“cure” γ-radiation-induced double-strand DNA breaks. The phenomenon of prolongation of MGE transposition induction during early generations after treatment was shown. In this period (F1–F12), the maximum transposition rate (λ ≃ 2 × 10–2events per MGE copy, per haploid genome, per generation) and the maximum number of heterozygous MGE copies were achieved. In the late generations (F140–F170), the reduced induction level (λ ∼ 10–3) was established. In the population of effective size N e= 2000 individuals, this corresponds to the state when λ ≫ 1/4N e, i.e., when the transposition flow prevails over the MGE copy loss by genetic drift. These data together with some indirect evidence argue for the hypothesis that the spontaneous transposition rate is proportional to the average number of heterozygous MGE copies per diploid genome.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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