Drugs (2017) 77:1967–1986 https://doi.org/10.1007/s40265-017-0819-9 SYSTEMATIC REVIEW Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years 1,2 1,2 1,2 1,2 • • • G. Voegeli M. L. Cle ´ry-Melin N. Ramoz P. Gorwood Published online: 2 November 2017 Springer International Publishing AG 2017 Abstract abstracts and the reference lists of these articles completed Background Antidepressant drugs are widely prescribed, the search process. but response rates after 3 months are only around one- Results Executive functioning, theta activity in the rostral third, explaining the importance of the search of objec- Anterior Cingular Cortex (rACC), and polysomnographic tively measurable markers predicting positive treatment sleep measures could be considered as belonging to the best response. These markers are being developed in different objectively measured markers, with a combined d around 1 ﬁelds, with different techniques, sample sizes, costs, and and at least four positive studies. For inter-category com- efﬁciency. It is therefore difﬁcult to know which ones are parisons, the approaches that showed the highest effect sizes the most promising. are, in descending order, imaging (combined d between Objective Our purpose was to compute comparable (i.e., 0.703 and 1.353), electrophysiology (0.294–1.138), cogni- standardized)
Drugs – Springer Journals
Published: Nov 2, 2017
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