Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years

Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A... Drugs (2017) 77:1967–1986 https://doi.org/10.1007/s40265-017-0819-9 SYSTEMATIC REVIEW Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years 1,2 1,2 1,2 1,2 • • • G. Voegeli M. L. Cle ´ry-Melin N. Ramoz P. Gorwood Published online: 2 November 2017 Springer International Publishing AG 2017 Abstract abstracts and the reference lists of these articles completed Background Antidepressant drugs are widely prescribed, the search process. but response rates after 3 months are only around one- Results Executive functioning, theta activity in the rostral third, explaining the importance of the search of objec- Anterior Cingular Cortex (rACC), and polysomnographic tively measurable markers predicting positive treatment sleep measures could be considered as belonging to the best response. These markers are being developed in different objectively measured markers, with a combined d around 1 fields, with different techniques, sample sizes, costs, and and at least four positive studies. For inter-category com- efficiency. It is therefore difficult to know which ones are parisons, the approaches that showed the highest effect sizes the most promising. are, in descending order, imaging (combined d between Objective Our purpose was to compute comparable (i.e., 0.703 and 1.353), electrophysiology (0.294–1.138), cogni- standardized) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drugs Springer Journals

Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Medicine & Public Health; Pharmacotherapy; Pharmacology/Toxicology; Internal Medicine
ISSN
0012-6667
eISSN
1179-1950
D.O.I.
10.1007/s40265-017-0819-9
Publisher site
See Article on Publisher Site

Abstract

Drugs (2017) 77:1967–1986 https://doi.org/10.1007/s40265-017-0819-9 SYSTEMATIC REVIEW Progress in Elucidating Biomarkers of Antidepressant Pharmacological Treatment Response: A Systematic Review and Meta-analysis of the Last 15 Years 1,2 1,2 1,2 1,2 • • • G. Voegeli M. L. Cle ´ry-Melin N. Ramoz P. Gorwood Published online: 2 November 2017 Springer International Publishing AG 2017 Abstract abstracts and the reference lists of these articles completed Background Antidepressant drugs are widely prescribed, the search process. but response rates after 3 months are only around one- Results Executive functioning, theta activity in the rostral third, explaining the importance of the search of objec- Anterior Cingular Cortex (rACC), and polysomnographic tively measurable markers predicting positive treatment sleep measures could be considered as belonging to the best response. These markers are being developed in different objectively measured markers, with a combined d around 1 fields, with different techniques, sample sizes, costs, and and at least four positive studies. For inter-category com- efficiency. It is therefore difficult to know which ones are parisons, the approaches that showed the highest effect sizes the most promising. are, in descending order, imaging (combined d between Objective Our purpose was to compute comparable (i.e., 0.703 and 1.353), electrophysiology (0.294–1.138), cogni- standardized)

Journal

DrugsSpringer Journals

Published: Nov 2, 2017

References

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