Virology Division News 835 Arch Virol 144/4 (1999) Virology Division News VDN M. Schwemmle Institut für Medizinische Mikrobiologie und Hygiene, Freiburg, Federal Republic of Germany Introduction Borna disease virus (BDV) is the type species of a new family, Bornaviridae, within the nonsegmented negative-strand RNA viruses (Mononegavirales). Unlike other members of the order Mononegavirales BDV replicates and transcribes in the nucleus and uses the splicing machinery for modification of subgenomic RNAs. The host range includes a broad variety of warmblooded animals and most likely humans. BDV is neurotropic and infection of immunocompetent animals can result in Borna disease (BD), an immune-mediated brain disorder, characterised by prominent disturbances of movement and behaviour. First hints that BDV could also be associated with certain human diseases emerged from serological studies beginning in the 80’s when psychiatric patients were found to be seropositive in an indirect immunfluorescence assay (IFA). Ever since then, the question of whether BDV infections cause psychiatric disorders in humans has remained a controversial issue. An international meeting was held in Freiburg* to discuss progress and controversial topics in Bornavirus research. Among the highlights were aspects of the molecular biology of BDV, the neuropathology of BDV-infected animals and first reports on
Archives of Virology – Springer Journals
Published: Apr 1, 1999
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