Prognostic factors affecting outcomes in fistulating perianal Crohn’s disease: a systematic review

Prognostic factors affecting outcomes in fistulating perianal Crohn’s disease: a systematic review Tech Coloproctol (2017) 21:501–519 DOI 10.1007/s10151-017-1647-3 REVIEW Prognostic factors affecting outcomes in fistulating perianal Crohn’s disease: a systematic review 1 1,2 3 2,3 • • • G. C. Braithwaite M. J. Lee D. Hind S. R. Brown Received: 1 February 2017 / Accepted: 22 May 2017 / Published online: 20 June 2017 The Author(s) 2017. This article is an open access publication Abstract mutations decreased response of fistulae to antibiotics. Background One in three patients with Crohn’s disease Complexity of fistulae anatomy was implicated in prog- will develop a perianal fistulae, and one third of these will nosis by 4 studies. achieve long-term healing or closure. A barrier to con- Conclusions This systematic review has identified potential ducting well-designed clinical trials for these patients is a prognostic markers, including genetic factors and disease lack of understanding of prognostic factors. This system- behaviour. We cannot, however, draw robust conclusions atic review sets out to identify factors associated with from this heterogeneous group of studies; therefore, we prognosis of perianal Crohn’s fistulae. recommend that a prospective cohort study of well-charac- Methods This review was registered on the PROSPERO terised patients with Crohn’s perianal fistulae is undertaken. database (CRD42016050316) and conducted in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Techniques in Coloproctology Springer Journals

Prognostic factors affecting outcomes in fistulating perianal Crohn’s disease: a systematic review

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Surgery; Gastroenterology; Proctology; Abdominal Surgery; Colorectal Surgery
ISSN
1123-6337
eISSN
1128-045X
D.O.I.
10.1007/s10151-017-1647-3
Publisher site
See Article on Publisher Site

Abstract

Tech Coloproctol (2017) 21:501–519 DOI 10.1007/s10151-017-1647-3 REVIEW Prognostic factors affecting outcomes in fistulating perianal Crohn’s disease: a systematic review 1 1,2 3 2,3 • • • G. C. Braithwaite M. J. Lee D. Hind S. R. Brown Received: 1 February 2017 / Accepted: 22 May 2017 / Published online: 20 June 2017 The Author(s) 2017. This article is an open access publication Abstract mutations decreased response of fistulae to antibiotics. Background One in three patients with Crohn’s disease Complexity of fistulae anatomy was implicated in prog- will develop a perianal fistulae, and one third of these will nosis by 4 studies. achieve long-term healing or closure. A barrier to con- Conclusions This systematic review has identified potential ducting well-designed clinical trials for these patients is a prognostic markers, including genetic factors and disease lack of understanding of prognostic factors. This system- behaviour. We cannot, however, draw robust conclusions atic review sets out to identify factors associated with from this heterogeneous group of studies; therefore, we prognosis of perianal Crohn’s fistulae. recommend that a prospective cohort study of well-charac- Methods This review was registered on the PROSPERO terised patients with Crohn’s perianal fistulae is undertaken. database (CRD42016050316) and conducted in

Journal

Techniques in ColoproctologySpringer Journals

Published: Jun 20, 2017

References

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