Tech Coloproctol (2017) 21:501–519 DOI 10.1007/s10151-017-1647-3 REVIEW Prognostic factors affecting outcomes in ﬁstulating perianal Crohn’s disease: a systematic review 1 1,2 3 2,3 • • • G. C. Braithwaite M. J. Lee D. Hind S. R. Brown Received: 1 February 2017 / Accepted: 22 May 2017 / Published online: 20 June 2017 The Author(s) 2017. This article is an open access publication Abstract mutations decreased response of ﬁstulae to antibiotics. Background One in three patients with Crohn’s disease Complexity of ﬁstulae anatomy was implicated in prog- will develop a perianal ﬁstulae, and one third of these will nosis by 4 studies. achieve long-term healing or closure. A barrier to con- Conclusions This systematic review has identiﬁed potential ducting well-designed clinical trials for these patients is a prognostic markers, including genetic factors and disease lack of understanding of prognostic factors. This system- behaviour. We cannot, however, draw robust conclusions atic review sets out to identify factors associated with from this heterogeneous group of studies; therefore, we prognosis of perianal Crohn’s ﬁstulae. recommend that a prospective cohort study of well-charac- Methods This review was registered on the PROSPERO terised patients with Crohn’s perianal ﬁstulae is undertaken. database (CRD42016050316) and conducted in
Techniques in Coloproctology – Springer Journals
Published: Jun 20, 2017
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