Progesterone

Progesterone Reactions 1704, p325 - 2 Jun 2018 Sclerosing lipogranuloma: case report A 45-year-old woman developed sclerosing lipogranuloma following administration of progesterone injections which contained soya oil emulsion [soyabean oil] to prevent miscarriages [duration of treatment to reaction onset and outcome not stated]. The woman presented with 1 year history of painful masses on her buttocks and waist. Prior to the symptoms appearance, she had been administered a constant IM progesterone injection 100mg twice a day in her buttocks for six weeks to prevent miscarriages. She also complained that the masses could migrate from her hip to her waist. A physical examination revealed four flesh coloured masses, 6 15cm in diameter, present on her buttocks and waist. She reported that the pain aggravated by touching or walking. An ultrasonography of the masses showed hypoechoic deposits predominating in the subcutaneous tissue. Histopathology of the two specimens taken from the mass lesions on her hip and waist revealed many granulomas consisting of foreign body giant cells with an infiltration of sparse lymphocytes in the subcutaneous tissue. Some varied cavities, translucent refractive colloid and eosinophilic amorphous materials were present inside the granulomas. A sclerosing lipogranuloma because of progesterone injections was diagnosed. Progesterone injections consisted of excipients such as soya oil emulsion and benzyl alcohol. Soya oil emulsion was concluded as a culprit for the development of sclerosing lipogranuloma. Author comment: "Our patient manifested rarely with giant masses located on her buttocks and waist and was induced by large-dose progesterone injections. Progesterone injections, which contain soybean oil and benzyl alcohol, are metabolized in the liver and excreted through urine. Hence, we hypothesize that: (i) [soya-oil-emulsion] may be the culprit, which cannot be metabolized completely in a short period of time". Li Z, et al. Sclerosing lipogranuloma presenting as movable masses induced by large doses of progesterone injection. Journal of Dermatology 45: e114-e115, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/1346-8138.14177 - China 803323325 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Progesterone

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46968-0
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p325 - 2 Jun 2018 Sclerosing lipogranuloma: case report A 45-year-old woman developed sclerosing lipogranuloma following administration of progesterone injections which contained soya oil emulsion [soyabean oil] to prevent miscarriages [duration of treatment to reaction onset and outcome not stated]. The woman presented with 1 year history of painful masses on her buttocks and waist. Prior to the symptoms appearance, she had been administered a constant IM progesterone injection 100mg twice a day in her buttocks for six weeks to prevent miscarriages. She also complained that the masses could migrate from her hip to her waist. A physical examination revealed four flesh coloured masses, 6 15cm in diameter, present on her buttocks and waist. She reported that the pain aggravated by touching or walking. An ultrasonography of the masses showed hypoechoic deposits predominating in the subcutaneous tissue. Histopathology of the two specimens taken from the mass lesions on her hip and waist revealed many granulomas consisting of foreign body giant cells with an infiltration of sparse lymphocytes in the subcutaneous tissue. Some varied cavities, translucent refractive colloid and eosinophilic amorphous materials were present inside the granulomas. A sclerosing lipogranuloma because of progesterone injections was diagnosed. Progesterone injections consisted of excipients such as soya oil emulsion and benzyl alcohol. Soya oil emulsion was concluded as a culprit for the development of sclerosing lipogranuloma. Author comment: "Our patient manifested rarely with giant masses located on her buttocks and waist and was induced by large-dose progesterone injections. Progesterone injections, which contain soybean oil and benzyl alcohol, are metabolized in the liver and excreted through urine. Hence, we hypothesize that: (i) [soya-oil-emulsion] may be the culprit, which cannot be metabolized completely in a short period of time". Li Z, et al. Sclerosing lipogranuloma presenting as movable masses induced by large doses of progesterone injection. Journal of Dermatology 45: e114-e115, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/1346-8138.14177 - China 803323325 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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