Using the bovine αS1-casein gene, a genetic construct with an endostatin-coding fragment of the mouse collagen XVIII cDNA was designed to express endostatin in milk of transgenic animals. Several transgenic mice were obtained. The mice secreted endostatin in milk at 70–300 ng/μl and transmitted this character to their progeny.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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