Mol Imaging Biol (2016) 18 (Suppl 2):S 1Y S1278 DOI: 10.1007/s11307-016-1031-0 Found 785 Records CONTROL ID: 2487222 TITLE: Quantifying Cardiac Fibrosis in Renal Failure Patients Using Gadolinium-Free Molecular MRI PRESENTER: Tori Stromp ABSTRACT BODY: Abstract Body: BACKGROUND: Patients with renal failure (RF) on routine hemodialysis suffer high rates of arrhythmia and sudden cardiac death, yet are contraindicated to standard gadolinium-based MRI fibrosis imaging. Consequently, detection of cardiac fibrosis relies on indirect measures including ventricular hypertrophy or reduced longitudinal or diastolic function. Magnetization transfer (MT) weighting in balanced steady state free precession (bSSFP) images can be used as an endogenous contrast mechanism to identify fibrotic and edematous tissue in close agreement with the clinical standard late gadolinium enhancement1 (Fig S1). We hypothesized that using MT-weighted MRI, RF patients would demonstrate increased cardiac fibrosis compared to healthy controls, despite similar contractile function. METHODS: 19 RF patients and 11 healthy controls have completed MT-fibrosis imaging as described in1. Prospectively gated cine bSSFP images were obtained on a 1.5T Siemens Aera scanner at flip angles of 5° and 45° covering the left ventricle. Maps of cardiac ΔS/S were generated as ΔS/S =(S -S )/S *100(%), where S is voxel o o 45 5
Molecular Imaging and Biology – Springer Journals
Published: Nov 21, 2016
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