Proceedings of the World Molecular Imaging Congress 2016, New York, New York, September 7-10, 2016: General Abstracts

Proceedings of the World Molecular Imaging Congress 2016, New York, New York, September 7-10,... Mol Imaging Biol (2016) 18 (Suppl 2):S 1Y S1278 DOI: 10.1007/s11307-016-1031-0 Found 785 Records CONTROL ID: 2487222 TITLE: Quantifying Cardiac Fibrosis in Renal Failure Patients Using Gadolinium-Free Molecular MRI PRESENTER: Tori Stromp ABSTRACT BODY: Abstract Body: BACKGROUND: Patients with renal failure (RF) on routine hemodialysis suffer high rates of arrhythmia and sudden cardiac death, yet are contraindicated to standard gadolinium-based MRI fibrosis imaging. Consequently, detection of cardiac fibrosis relies on indirect measures including ventricular hypertrophy or reduced longitudinal or diastolic function. Magnetization transfer (MT) weighting in balanced steady state free precession (bSSFP) images can be used as an endogenous contrast mechanism to identify fibrotic and edematous tissue in close agreement with the clinical standard late gadolinium enhancement1 (Fig S1). We hypothesized that using MT-weighted MRI, RF patients would demonstrate increased cardiac fibrosis compared to healthy controls, despite similar contractile function. METHODS: 19 RF patients and 11 healthy controls have completed MT-fibrosis imaging as described in1. Prospectively gated cine bSSFP images were obtained on a 1.5T Siemens Aera scanner at flip angles of 5° and 45° covering the left ventricle. Maps of cardiac ΔS/S were generated as ΔS/S =(S -S )/S *100(%), where S is voxel o o 45 5 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Imaging and Biology Springer Journals

Proceedings of the World Molecular Imaging Congress 2016, New York, New York, September 7-10, 2016: General Abstracts

Proceedings of the World Molecular Imaging Congress 2016, New York, New York, September 7-10, 2016: General Abstracts

Mol Imaging Biol (2016) 18 (Suppl 2):S 1Y S1278 DOI: 10.1007/s11307-016-1031-0 Found 785 Records CONTROL ID: 2487222 TITLE: Quantifying Cardiac Fibrosis in Renal Failure Patients Using Gadolinium-Free Molecular MRI PRESENTER: Tori Stromp ABSTRACT BODY: Abstract Body: BACKGROUND: Patients with renal failure (RF) on routine hemodialysis suffer high rates of arrhythmia and sudden cardiac death, yet are contraindicated to standard gadolinium-based MRI fibrosis imaging. Consequently, detection of cardiac fibrosis relies on indirect measures including ventricular hypertrophy or reduced longitudinal or diastolic function. Magnetization transfer (MT) weighting in balanced steady state free precession (bSSFP) images can be used as an endogenous contrast mechanism to identify fibrotic and edematous tissue in close agreement with the clinical standard late gadolinium enhancement1 (Fig S1). We hypothesized that using MT-weighted MRI, RF patients would demonstrate increased cardiac fibrosis compared to healthy controls, despite similar contractile function. METHODS: 19 RF patients and 11 healthy controls have completed MT-fibrosis imaging as described in1. Prospectively gated cine bSSFP images were obtained on a 1.5T Siemens Aera scanner at flip angles of 5° and 45° covering the left ventricle. Maps of cardiac ΔS/S were generated as ΔS/S =(S -S )/S *100(%), where S is voxel o o 45 5 5 i signal intensity at flip angle i (Fig S2). A feature tracking algorithm measured longitudinal strain and mid ventricular diastolic strain rate2 (Fig S3). To assess diffuse fibrosis (Figure 1) we used statistical comparison of the distribution of myocardial ΔS/S values per individual against a control distribution (Fig S4). The average ΔS/S distribution over all o o control hearts served as a reference healthy standard. To account for heart size variation, the standard was dynamically resized to simulate a cumulative distribution function of ΔS/S for a...
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Publisher
Springer US
Copyright
Copyright © 2016 by World Molecular Imaging Society
Subject
Medicine & Public Health; Imaging / Radiology
ISSN
1536-1632
eISSN
1860-2002
D.O.I.
10.1007/s11307-016-1031-0
Publisher site
See Article on Publisher Site

Abstract

Mol Imaging Biol (2016) 18 (Suppl 2):S 1Y S1278 DOI: 10.1007/s11307-016-1031-0 Found 785 Records CONTROL ID: 2487222 TITLE: Quantifying Cardiac Fibrosis in Renal Failure Patients Using Gadolinium-Free Molecular MRI PRESENTER: Tori Stromp ABSTRACT BODY: Abstract Body: BACKGROUND: Patients with renal failure (RF) on routine hemodialysis suffer high rates of arrhythmia and sudden cardiac death, yet are contraindicated to standard gadolinium-based MRI fibrosis imaging. Consequently, detection of cardiac fibrosis relies on indirect measures including ventricular hypertrophy or reduced longitudinal or diastolic function. Magnetization transfer (MT) weighting in balanced steady state free precession (bSSFP) images can be used as an endogenous contrast mechanism to identify fibrotic and edematous tissue in close agreement with the clinical standard late gadolinium enhancement1 (Fig S1). We hypothesized that using MT-weighted MRI, RF patients would demonstrate increased cardiac fibrosis compared to healthy controls, despite similar contractile function. METHODS: 19 RF patients and 11 healthy controls have completed MT-fibrosis imaging as described in1. Prospectively gated cine bSSFP images were obtained on a 1.5T Siemens Aera scanner at flip angles of 5° and 45° covering the left ventricle. Maps of cardiac ΔS/S were generated as ΔS/S =(S -S )/S *100(%), where S is voxel o o 45 5

Journal

Molecular Imaging and BiologySpringer Journals

Published: Nov 21, 2016

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