S4 Proceedings of the 2011 World Molecular Imaging Congress Presentation Number P001 Poster Session 4 September 10, 2011 / 14:45-16:15 / Room: Hall F Epidermal Growth Factor Receptor Specific Gold Nanorods for Molecular Imaging of Pancreatic Cancer Nripen Chanda, Ajit Zambre, Charles Caldwell, Ravi Shukla, Evan J. Boote, Kattesh V. Katti, Raghuraman Kannan, Radiology, University of Missouri, Columbia, MO, USA. Contact e-mail: email@example.com Epidermal Growth Factor Receptor (EGFR) plays a vital role in the growth and propagation of mammalian tumors. EGFR has been recognized to be a clinically significant target as between 70 to 90% of all pancreatic tumors over express EGF receptors. Based on the clinical evidence, it is clear that targeting EGF receptors would be a viable and attractive approach for developing targeted molecular imaging agents. Among various targeting approaches, receptor-avid peptides have advantages over larger proteins. In this study, we have utilized a novel EGF-receptor avid peptide sequence “YHWYGYTPQNVI” (GE11) as a biomarker to target pancreatic cancer. Our investigation establishes that the GE11 peptide conjugated GNR have high in vitro and in vivo target specificity towards EGF receptors. Also, we have examined the utility of GNR-GE11 as X-ray contrast agents. In this poster, we will present
Molecular Imaging and Biology – Springer Journals
Published: Feb 4, 2012
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