Proceedings of the 2011 World Molecular Imaging Congress, San Diego, CA, USA, September 7-10, 2011

Proceedings of the 2011 World Molecular Imaging Congress, San Diego, CA, USA, September 7-10, 2011 S4 Proceedings of the 2011 World Molecular Imaging Congress Presentation Number P001 Poster Session 4 September 10, 2011 / 14:45-16:15 / Room: Hall F Epidermal Growth Factor Receptor Specific Gold Nanorods for Molecular Imaging of Pancreatic Cancer Nripen Chanda, Ajit Zambre, Charles Caldwell, Ravi Shukla, Evan J. Boote, Kattesh V. Katti, Raghuraman Kannan, Radiology, University of Missouri, Columbia, MO, USA. Contact e-mail: kannanr@health.missouri.edu Epidermal Growth Factor Receptor (EGFR) plays a vital role in the growth and propagation of mammalian tumors. EGFR has been recognized to be a clinically significant target as between 70 to 90% of all pancreatic tumors over express EGF receptors. Based on the clinical evidence, it is clear that targeting EGF receptors would be a viable and attractive approach for developing targeted molecular imaging agents. Among various targeting approaches, receptor-avid peptides have advantages over larger proteins. In this study, we have utilized a novel EGF-receptor avid peptide sequence “YHWYGYTPQNVI” (GE11) as a biomarker to target pancreatic cancer. Our investigation establishes that the GE11 peptide conjugated GNR have high in vitro and in vivo target specificity towards EGF receptors. Also, we have examined the utility of GNR-GE11 as X-ray contrast agents. In this poster, we will present http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Imaging and Biology Springer Journals

Proceedings of the 2011 World Molecular Imaging Congress, San Diego, CA, USA, September 7-10, 2011

Proceedings of the 2011 World Molecular Imaging Congress, San Diego, CA, USA, September 7-10, 2011

S4 Proceedings of the 2011 World Molecular Imaging Congress Presentation Number P001 Poster Session 4 September 10, 2011 / 14:45-16:15 / Room: Hall F Epidermal Growth Factor Receptor Specific Gold Nanorods for Molecular Imaging of Pancreatic Cancer Nripen Chanda, Ajit Zambre, Charles Caldwell, Ravi Shukla, Evan J. Boote, Kattesh V. Katti, Raghuraman Kannan, Radiology, University of Missouri, Columbia, MO, USA. Contact e-mail: kannanr@health.missouri.edu Epidermal Growth Factor Receptor (EGFR) plays a vital role in the growth and propagation of mammalian tumors. EGFR has been recognized to be a clinically significant target as between 70 to 90% of all pancreatic tumors over express EGF receptors. Based on the clinical evidence, it is clear that targeting EGF receptors would be a viable and attractive approach for developing targeted molecular imaging agents. Among various targeting approaches, receptor-avid peptides have advantages over larger proteins. In this study, we have utilized a novel EGF-receptor avid peptide sequence “YHWYGYTPQNVI” (GE11) as a biomarker to target pancreatic cancer. Our investigation establishes that the GE11 peptide conjugated GNR have high in vitro and in vivo target specificity towards EGF receptors. Also, we have examined the utility of GNR-GE11 as X-ray contrast agents. In this poster, we will present the following aspects of this investigation: (i) synthesis, bio-conjugation, and physiochemical characterization of GNR-GE11 conjugates; (ii) In vitro EGF receptor targeting ability; (iii) In vivo EGF-receptor targeting ability in mice models; and (iv) Utility of GNR-GE11 as molecular contrast agents. Dark field images showing (A) Fixed Panc-1 cells untreated; (B) Fixed Panc-1 cells treated with AuNP-GE11; (C) Fixed Panc-1 cells treated with AuNP- PEG; (D) Bio-distribution data showing in vivo targeting characteristics of AuNP-GE11 in pancreatic tumor bearing mice (determined using NAA techniques). Disclosure of author...
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Publisher
Springer-Verlag
Copyright
Copyright © 2012 by World Molecular Imaging Society
Subject
Medicine & Public Health; Imaging / Radiology
ISSN
1536-1632
eISSN
1860-2002
D.O.I.
10.1007/s11307-012-0543-5
Publisher site
See Article on Publisher Site

Abstract

S4 Proceedings of the 2011 World Molecular Imaging Congress Presentation Number P001 Poster Session 4 September 10, 2011 / 14:45-16:15 / Room: Hall F Epidermal Growth Factor Receptor Specific Gold Nanorods for Molecular Imaging of Pancreatic Cancer Nripen Chanda, Ajit Zambre, Charles Caldwell, Ravi Shukla, Evan J. Boote, Kattesh V. Katti, Raghuraman Kannan, Radiology, University of Missouri, Columbia, MO, USA. Contact e-mail: kannanr@health.missouri.edu Epidermal Growth Factor Receptor (EGFR) plays a vital role in the growth and propagation of mammalian tumors. EGFR has been recognized to be a clinically significant target as between 70 to 90% of all pancreatic tumors over express EGF receptors. Based on the clinical evidence, it is clear that targeting EGF receptors would be a viable and attractive approach for developing targeted molecular imaging agents. Among various targeting approaches, receptor-avid peptides have advantages over larger proteins. In this study, we have utilized a novel EGF-receptor avid peptide sequence “YHWYGYTPQNVI” (GE11) as a biomarker to target pancreatic cancer. Our investigation establishes that the GE11 peptide conjugated GNR have high in vitro and in vivo target specificity towards EGF receptors. Also, we have examined the utility of GNR-GE11 as X-ray contrast agents. In this poster, we will present

Journal

Molecular Imaging and BiologySpringer Journals

Published: Feb 4, 2012

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