Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer_journal/priming-with-two-dna-vaccines-expressing-hepatitis-c-virus-ns3-protein-0iI6d00J0N
References (37)
-
C Neumann-Haefelin, R Thimme (2013)
Adaptive immune responses in hepatitis C virus infectionCurr Top Microbiol Immunol, 369
-
M Mikkelsen, PJ Holst, J Bukh, AR Thomsen, JP Christensen (2011)
Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chainJ Immunol, 186
-
A Folgori (2006)
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzeesNat Med, 12
-
L Arribillaga, AL de Cerio, P Sarobe, P Sarobe, N Casares, M Gorriaiz, A Vales, O Bruna-Romero, F Borras-Cuesta, G Paranhos-Baccala, J Prieto, J Ruiz, JJ Lasarte (2002)
Vaccination with an adenoviral vector encoding hepatitis C virus (HCV) NS3 protein protects against infection with HCV-recombinant vaccinia virusVaccine, 21
-
A Fournillier, L Frelin, E Jacquier, G Ahlén, A Brass, E Gerossier, F Holmström, KE Broderick, NY Sardesai, JY Bonnefoy, G Inchauspé, M Sällberg (2013)
A heterologous prime/boost vaccination strategy enhances the immunogenicity of therapeutic vaccines for hepatitis C virusJ Infect Dis, 208
-
M Houghton (2011)
99Immunol Rev, 239
-
F Habersetzer, TF Baumert, F Stoll-Keller (2009)
GI-5005, a yeast vector vaccine expressing an NS3-core fusion protein for chronic HCV infectionCurr Opin Mol Ther, 11
-
E Barnes, A Folgori, S Capone, L Swadling, S Aston, A Kurioka, J Meyer, R Huddart, K Smith, R Townsend, A Brown, R Antrobus, V Ammendola, M Naddeo, G O’Hara, C Willberg, A Harrison, F Grazioli, ML Esposito, L Siani, C Traboni, Y Oo, D Adams, A Hill, S Colloca, A Nicosia, R Cortese, P Klenerman (2012)
Novel adenovirus-basedvaccines induce broad and sustained T cell responses to HCV in manSci Transl Med, 4
-
KF Hsu, CF Hung, WF Cheng, L He, LA Slater, M Ling, TC Wu (2001)
Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigenGene Ther, 8
-
X Yin, W Wang, WJ Tan, Y Deng, J Guan, B Wen, H Chen, L Ruan (2011)
Enhancement of the immune response in mice with a noval HCV DNA vaccine targeting NS3 to dendritic cellsBing Du Xue Bao, 27
-
N Tatsis, HC Ertl (2004)
Adenoviruses as vaccine vectorsMol Ther, 10
-
PP Ip, A Boerma, J Regts, T Meijerhof, J Wilschut, HW Nijman, T Daemen (2014)
Alphavirus-based vaccines encoding nonstructural proteins of hepatitis C virus induce robust and protective T-cell responsesMol Ther, 22
-
J Guan, B Wen, Y Deng, K Zhang, H Chen, X Wu, L Ruan, W Tan (2011)
Effect of route of delivery on heterologous protection against HCV induced by an adenovirus vector carrying HCV structural genesVirol J, 4
-
C Shi (2013)
171Expert Rev Gastroenterol Hepatol, 7
-
SJ Draper, JL Heeney (2010)
Viruses as vaccine vectors for infectious diseases and cancerNat Rev Microbial, 8
-
CM Lange (2013)
583J Hepatol, 58
-
DH Barouch (2006)
Rational design of gene-based vaccinesJ Pathol, 208
-
JP Messina, I Humphreys, A Flaxman, A Brown, GS Cooke, OG Pybus, E Barnes (2014)
Global distribution and prevalence of hepatitis C virus genotypesHepatology
-
HM Diepolder, R Zachoval, RM Hoffmann, EA Wierenga, T Santantonio, MC Jung, D Eichenlaub, GR Pape (1995)
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infectionLancet, 346
-
H Chen, B Wen, Y Deng, W Wang, X Yin, J Guan, L Ruan, W Tan (2011)
Enhanced effect of DNA immunization plus In Vivo electorporation with a combination of Hepatitis B Virus Core-PreS1 and S-PreS1 plasmidsClin Vaccine Immunol, 18
-
TW Kim, CF Hung, J Juang, L He, JM Hardwick, TC Wu (2004)
Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell deathGene Ther, 11
-
M Matsui, O Moriya, T Akatsuka (2003)
Enhanced induction of hepatitis C virus-specific cytotoxic T lymphocytes and protective efficacy in mice by DNA vaccination followed by adenovirus boosting in combination with the interleukin-12 expression plasmidVaccine, 21
-
G Ahlén, F Holmström, A Gibbs, M Alheim, L Frelin (2014)
Long-term functional duration of immune responses to HCV NS3/4A induced by DNA vaccinationGene Ther., 21
-
D Lavanchy (2011)
107Clin Microbiol Infect, 17
-
C Neumann-Haefelin (2013)
243Curr Top Microbiol Immunol, 369
-
U Chatterji (2014)
3327Antimicrob Agents Chemother, 58
-
BE Verstrepen, EJ Verschoor, ZC Fagrouch, P Mooij, NG de Groot, RE Bontrop, WM Bogers, JL Heeney, G Koopman (2014)
Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infectionPLoS One, 9
-
GT Everson (2014)
420Gastroenterology, 146
-
SA Abdulhaqq, DB Weiner (2008)
DNA vaccines: developing new strategies to enhance immune responsesImmunol Res, 42
-
G Nchinda, J Kuroiwa, M Oks, C Trumpfheller, CG Park, Y Huang, D Hannaman, SJ Schlesinger, O Mizenina, MC Nussenzweig, K Uberla, RM Steinman (2008)
The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cellsJ Clin Invest, 118
-
K Murata, M Lechmann, M Qiao, T Gunji, HJ Alter, TJ Liang (2003)
Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infectionProc Natl Acad Sci USA, 100
-
C Grossmann, M Tenbusch, G Nchinda, V Temchura, G Nabi, GW Stone, RS Kornbluth, K Uberla (2009)
Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligandsBMC Immunol, 10
-
KA Lang Kuhs, AA Ginsberg, J Yan, RW Wiseman, AS Khan, NY Sardesai, DH O’Connor, DB Weiner (2012)
Hepatitis C virus NS3/NS4A DNA vaccine induces multiepitope T cell responses in rhesus macaques mimicking human immune responses [corrected]Mol Ther, 20
-
SB Boscardin, JCR Hafalla, RF Masilamani, AO Kamphorst, HA Zebroski, U Rai, A Morrot, F Zavala, RM Steinman, RS Nussenzweig, MC Nussenzweig (2006)
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responsesJ Exp Med, 203
-
DH Barouch, ZY Yang, WP Kong, B Korioth-Schmitz, SM Sumida, DM Truitt, MG Kishko, JC Arthur, A Miura, JR Mascola, NL Letvin, GJ Nabel (2005)
A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primatesJ Virol, 79
-
S Colloca, E Barnes, A Folgori, V Ammendola, S Capone, A Cirillo, L Siani, M Naddeo, F Grazioli, ML Esposito, M Ambrosio, A Sparacino, M Bartiromo, A Meola, K Smith, A Kurioka, GA O’Hara, KJ Ewer, N Anagnostou, C Bliss, AV Hill, C Traboni, P Klenerman, R Cortese, A Nicosia (2012)
Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple speciesSci Transl Med, 4
-
X Yin, J Lu, W Tan (2010)
Enhancement of the immune response of a novel DNA vaccine encoding conserved NS3 and Core fusion gene of HCV injected by intradermal electrotransfer in miceChin J Microbiol Immunol, 30
- Publisher
- Springer Journals
- Copyright
- Copyright © Springer-Verlag Wien 2015
- Subject
- Biomedicine; Virology; Medical Microbiology; Infectious Diseases
- ISSN
- 0304-8608
- eISSN
- 1432-8798
- DOI
- 10.1007/s00705-015-2535-7
- pmid
- 26215441
- Publisher site
- See Article on Publisher Site
Abstract
Development an effective vaccine may offer an alternative preventive and therapeutic strategy against HCV infection. DNA vaccination has been shown to induce robust humoral and cellular immunity and overcome many problems associated with conventional vaccines. In this study, mice were primed with either conventional pVRC-based or suicidal pSC-based DNA vaccines carrying DEC-205-targeted NS3 antigen (DEC-NS3) and boosted with type 5 adenoviral vectors encoding the partial NS3 and core antigens (C44P). The prime boost regimen induced a marked increase in antigen-specific humoral and T-cell responses in comparison with either rAd5-based vaccines or DEC-205-targeted DNA immunization in isolation. The protective effect against heterogeneous challenge was correlated with high levels of anti-NS3 IgG and T-cell-mediated immunity against NS3 peptides. Moreover, priming with a suicidal DNA vaccine (pSC-DEC-NS3), which elicited increased TNF-α-producing CD4+ and CD8+ T-cells against NS3-2 peptides (aa 1245–1461), after boosting, showed increased heterogeneous protective potential compared with priming with a conventional DNA vaccine (pVRC-DEC-NS3). In conclusion, a suicidal DNA vector (pSC-DEC-NS3) expressing DEC-205-targeted NS3 combined with boosting using an rAd5-based HCV vaccine (rAd5-C44P) is a good candidate for a safe and effective vaccine against HCV infection.
Journal
Archives of Virology – Springer Journals
Published: Oct 1, 2015
Keywords: Peptide Pool; Intracellular Cytokine Staining; Semliki Forest Virus Replicon; Vaccinia Virus Titre