Primary Mucosal Melanoma of the Vagina: About a Case Treated by External Beam Radiotherapy and High-Dose-Rate Brachytherapy

Primary Mucosal Melanoma of the Vagina: About a Case Treated by External Beam Radiotherapy and... Background Vaginal melanoma is an extremely rare entity. It is an aggressive disease with a poor prognosis and short-term survival related to high rate of local and distant recurrences. Treatment modalities are not codified and include surgery, radiotherapy and chemotherapy. Radiotherapy is always used as adjuvant treatment after wide local excision, but there are little data about its use as an exclusive treatment or after partial surgery. Case We report the case of vaginal melanoma in 31-year-old Arabic woman. The patient refused radical surgery, and partial surgery was performed followed by hypofractionated external beam radiotherapy at the dose of 20 Gy in 5 daily fractions of 5 Gy week (biologic effective dose = 53.33 Gy for melanoma a/b = 3), to the entire pelvis including inguinal lymph nodes; then, the tumor bed was boosted by high-dose-rate brachytherapy at the dose of 28 Gy in 4 fractions of 7 Gy. After 12 months of follow-up, the patient is free of local or distant recurrence. Conclusion Radiotherapy is an effective therapeutic modality of vaginal melanoma, especially when radical surgery is not feasible or refused. Radiation oncologist must integrate radio-biologic characteristics of melanoma in the choice of dose fractionation. Keywords Vaginal melanoma http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Gynecologic Oncology Springer Journals

Primary Mucosal Melanoma of the Vagina: About a Case Treated by External Beam Radiotherapy and High-Dose-Rate Brachytherapy

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Publisher
Springer India
Copyright
Copyright © 2018 by Association of Gynecologic Oncologists of India
Subject
Medicine & Public Health; Oncology; Surgical Oncology
ISSN
2363-8397
eISSN
2363-8400
D.O.I.
10.1007/s40944-018-0200-2
Publisher site
See Article on Publisher Site

Abstract

Background Vaginal melanoma is an extremely rare entity. It is an aggressive disease with a poor prognosis and short-term survival related to high rate of local and distant recurrences. Treatment modalities are not codified and include surgery, radiotherapy and chemotherapy. Radiotherapy is always used as adjuvant treatment after wide local excision, but there are little data about its use as an exclusive treatment or after partial surgery. Case We report the case of vaginal melanoma in 31-year-old Arabic woman. The patient refused radical surgery, and partial surgery was performed followed by hypofractionated external beam radiotherapy at the dose of 20 Gy in 5 daily fractions of 5 Gy week (biologic effective dose = 53.33 Gy for melanoma a/b = 3), to the entire pelvis including inguinal lymph nodes; then, the tumor bed was boosted by high-dose-rate brachytherapy at the dose of 28 Gy in 4 fractions of 7 Gy. After 12 months of follow-up, the patient is free of local or distant recurrence. Conclusion Radiotherapy is an effective therapeutic modality of vaginal melanoma, especially when radical surgery is not feasible or refused. Radiation oncologist must integrate radio-biologic characteristics of melanoma in the choice of dose fractionation. Keywords Vaginal melanoma

Journal

Indian Journal of Gynecologic OncologySpringer Journals

Published: Apr 19, 2018

References

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